Varicella Zoster Flashcards Preview

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Flashcards in Varicella Zoster Deck (13)
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1
Q

What is Varicella (zoster)?

A

Primary infection

Successive crops of lesions in a specific area of skin

2
Q

What are the complications of varicella?

A

Pneumonitits in adults, X-ray calcified nodules

Encephalitis in children (males 2x more than females)

Hemorrhagic varicella, bleeding in vesicles, GUT, GU

3
Q

What is reyes syndrome?

A

Aspirin related complication of varicella

Hepatic failure, encephalopathy

4
Q

What is Herpes Zoster?

A

Reccurent varicella infection

Adults - located on the dermatome innervated by the affected sensory nerve. Lesions are unilateral

5
Q

Where is the varicella virus latent location?

A

Dorsal root ganglia

6
Q

What is the pathogenesis for the primary varicella infection?

A

Respiratory route –> viremia –> skin

Leads to macular-papular, vsicular, not umbilicated lestions

Crusts are not infectious, each crop of lesions arise in asynchronous progression

7
Q

What is the incubation period for varicella?

A

Two weeks

Fever with each crop outbreak, wide spread rash produces higher fever

Spreads from trunk to face

8
Q

How can Zoster be activated?

A

X-rays

Tumor in CNS

Taruma

Immunosuppression

9
Q

What is the treatment for zoster lesions?

A

Zoster Immune Globulin (ZIG)

Prevents complications, neutralizes VZ-virus

10
Q

What is the routine vaccination for children for varicella?

A

Attenuated live vaccine

2 doses, 1 at 12-15 months, second at 4-6 years

11
Q

What are the two available varicella vaccines?

A

Single antigen vaccine (VARIVAX)

Combo vaccine (MMRV)

12
Q

What is the zoster vaccine?

A

Zostavax for individuals over 60, one immunization

13
Q

What is the treatment for immunosuppressed patients with V or Z?

A

Adenine arabinosdie

oral acyclovir

IV acyclovir for immunocompromised children