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Flashcards in Vasculitis Deck (28):
1

Name two large vessel vasculitis

Giant Cell Arteritis
Takayasu's arteritis

2

Name two medium vessel vasculitis

Polyarteritis Nodosa
Kawasaki disease
Buerger's disease

3

Small vessel

pANCA - Churg Strauss, Microscopic Polyangitis
cANCA - Granulomatosis with polyangitis
ANCA -'ve - Henoch Schonlein Purpura, good pastures disease

4

Giant cell Arteritis - four key symptoms

Painless loss of vision
Jaw claudication
Headache
Temporal artery & scalp tenderness

5

What blood tests in GCA?

ESR (up), ALP (UP) , HB (down)

6

How to treat GCA

Oral prednisolone 40-60mg

7

Who gets Takayasu's arteritis

Asian women who are less than 40 years . Giant cells in the aortic arch at branches.

8

3 key features of Takayasu's arteritis

Weak pulses in upper extremities
Visual disturbance
Hypertension

9

What lab test in Takayasu's

ESR

10

How treat Takayasu's

Corticosteroids

11

Who gets polyarteritis Nodosa?

Young, male adults. Immune confuses endothelium for Hep B

12

Features of polyarteritis nodosa?

Skin -> Rash
Renal -> HTN
GIT -> Melaena and abdo pain

13

How to diagnose polyarteritis nodosa?

String of beads on angiogram

14

Who gets Kawasaki's disease?

Young children

15

What are the 5 key features of Kawasaki's disease?

C onjunctivitis
R ash - polymorphic on trunk
A denopathy - cervical lympg
S trawberry tounge
H ands and feet (swollen and rash)

16

What happens to bloods in Kawasaki's?

Anaemia
Raised WBC, LFT, ESR, CRP

17

Management of kawasaki's

IV Ig + Aspirin

18

What did granulamoatosis polyangitis used to be called?

Wegners disease

19

What antibody is found in granulomatosis with polyangitis?

cANCA

20

What are the key features of GPA?

URT - chronic sinusitis, epistaxis, saddle-nose deformity
LRT - cough, haemoptysis, pleuritis
Renal - Rapidly progressive GN, haematuria & proteinuria
Other - Palpable purpura, ocular conjucticitis, keratitis, uveitis

21

How do you treat Wegners GPA?

Pred & cyclophosphamide

22

What is the autoantibody for eosinophillic GPA?

pANCA

23

What are the key features of eosinophillic GPA?

Late onset asthma
Eosinophillia
Paranasal sinusitis
Rapid progress GN

24

What investigations would you do in EGPA?

WBC -> Raised eosinophils
X-ray
Spirometry
ECG

25

Management for eGPA?

Steroids and cyclophosphamide

26

Describe Henoch Schonleins vasculitits

A child aged 3-8 years presents with a rash on buttocks following an URTI

27

What are the key features of henoch schonleins vasculitits?

Palpable purpuric rash on legs
Colicky abdominal pain
Arthralgia
Post-URT
Polyarthritis

28

What is the management of Henoch Schonlein's?

Pain relief
Supportive
Steroids if severe