Flashcards in Vasculitis Deck (28):
Name two large vessel vasculitis
Giant Cell Arteritis
Name two medium vessel vasculitis
pANCA - Churg Strauss, Microscopic Polyangitis
cANCA - Granulomatosis with polyangitis
ANCA -'ve - Henoch Schonlein Purpura, good pastures disease
Giant cell Arteritis - four key symptoms
Painless loss of vision
Temporal artery & scalp tenderness
What blood tests in GCA?
ESR (up), ALP (UP) , HB (down)
How to treat GCA
Oral prednisolone 40-60mg
Who gets Takayasu's arteritis
Asian women who are less than 40 years . Giant cells in the aortic arch at branches.
3 key features of Takayasu's arteritis
Weak pulses in upper extremities
What lab test in Takayasu's
How treat Takayasu's
Who gets polyarteritis Nodosa?
Young, male adults. Immune confuses endothelium for Hep B
Features of polyarteritis nodosa?
Skin -> Rash
Renal -> HTN
GIT -> Melaena and abdo pain
How to diagnose polyarteritis nodosa?
String of beads on angiogram
Who gets Kawasaki's disease?
What are the 5 key features of Kawasaki's disease?
R ash - polymorphic on trunk
A denopathy - cervical lympg
S trawberry tounge
H ands and feet (swollen and rash)
What happens to bloods in Kawasaki's?
Raised WBC, LFT, ESR, CRP
Management of kawasaki's
IV Ig + Aspirin
What did granulamoatosis polyangitis used to be called?
What antibody is found in granulomatosis with polyangitis?
What are the key features of GPA?
URT - chronic sinusitis, epistaxis, saddle-nose deformity
LRT - cough, haemoptysis, pleuritis
Renal - Rapidly progressive GN, haematuria & proteinuria
Other - Palpable purpura, ocular conjucticitis, keratitis, uveitis
How do you treat Wegners GPA?
Pred & cyclophosphamide
What is the autoantibody for eosinophillic GPA?
What are the key features of eosinophillic GPA?
Late onset asthma
Rapid progress GN
What investigations would you do in EGPA?
WBC -> Raised eosinophils
Management for eGPA?
Steroids and cyclophosphamide
Describe Henoch Schonleins vasculitits
A child aged 3-8 years presents with a rash on buttocks following an URTI
What are the key features of henoch schonleins vasculitits?
Palpable purpuric rash on legs
Colicky abdominal pain