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Flashcards in viral drugs I keep missing Deck (21)
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1
Q

the one drug used to treat pox virus family? hint: one of the ones with diff MOA

A

cidofovir

2
Q

3 drugs used to treat varicella zoster? FAV

A

acyclovir, valacyclovir, famciclovir

3
Q

2 drugs used to treat varicella chicken pox?

A

acyclovir, valacyclovir

4
Q

4 drugs used to treat HHV-6? 2 weird ones + 2 related ones

A

cidofovir, foscarnet, ganciclovir, valganciclovir

5
Q

one drug used to treat HHV-7?

A

cidofovir

6
Q

4 drugs used to treat HHV-8?

A

cidofovir, famciclovir, ganciclovir, valacyclovir

7
Q

2 drugs used to treat HHV-8 infection

A

ganciclovir and valganciclovir

8
Q

two antiviral drugs that do not require intracellular kinase-dependent phosphorylation for activity. they retain efficacy vs. kinase-deficient strains

A

cidofovir and forscarnet

9
Q

MOA for acyclovir, famciclovir, ganciclovir, valacyclovir, valganciclovir,

A

competitively inhibit viral DNA polymerase; competes with deoxyguanosine triphosphate for incorporation into viral DNA

10
Q

MOA for cidofovir

A

competitively inhibit viral DNA polymerase; compestes with deoxycytosine triphosphate for incorporation into viral DNA

11
Q

MOA for foscarnet

A

selectively inhibits the viral-specific DNA polymerases and reverse transcriptase at pyrophosphate binding site; blocks chain elongation

12
Q

ADE for acyclovir

A

neurotoxicity including seizures

13
Q

ADE for cidofovir

A

nephrotoxicity - monitor; creatinine and urinary protein; probenecid hypersensitivity

14
Q

ADE for famciclovir

A

NO significant issues!!

15
Q

ADE for foscarnet

A

electrolyte imbalance; chelates Ca2+ ions

16
Q

ADE for ganciclovir. think PANT LT

A

anemia, luekopenia, neutropenia, pancytopenia, and thrombocytopenia; teratogen

17
Q

ADE for valacyclovir

A

as for acyclovir (neurotoxicity including seizures)

18
Q

ADE for valganciclovir

A

as for ganciclovir (anemia, leukopenia, neutropenia, panyctopenia, and thrombocytopenia, teratogen)

19
Q

this drug is metabolized to penciclovir

A

famciclovir

20
Q

these two drugs are prodrugs

A

valacyclovir and valganciclovir

21
Q

why do patients receive oral probenecid while taking cidofovir

A

to minimize potential for renal toxicity, patients receive oral probenecid and hydration with normal saline concurrently