Vitamins and Cofactors Flashcards Preview

Foundations of Medicine (Week 1) > Vitamins and Cofactors > Flashcards

Flashcards in Vitamins and Cofactors Deck (7)
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1
Q

What are some examples of redox cofactors?

A

NADH

NADPH

FAD(2H)

Metals: Copper, Iron, etc

2
Q

Where do the H’s go in the NAD/Lactate Dehyrogenase RXN with Lactate?

A

Both leave lactate. One attaches to the Nicatinamide on FAD and one goes into solution.

3
Q

(T/F) Most enzymes use NAD or NADPH, but not both.

A

T

4
Q

When Pyruvate Dehydrogenase is on you get [ ] When it’s off you get [ ]

A

Glycolysis on and consumption of carbs; Glycolysis off and consumption of fatty acids. Decides whether yo burn or ferment carbs.

5
Q

What is the reaction type and formula concerning Pyruvate Dehydrogenase.

A

Oxidative decarboylation, redox reaction, acyl transfer reaction
NAD+ + pyruvate + CoASH  NADH + H+ + acetyl CoA + CO2

6
Q

In the Pyruvate Dehydrogenase reaction, what species carry out..
Decarboxylation:

Reduction and oxidation:

Transfer acyl group:

A

Decarboxylation: Thiamine pyrophosphate

Reduction and oxidation: NAD+ and FAD

Transfer acyl group: Lipoate and CoASH

7
Q

Which 4 Enzymes use Biotin?

A

acetyl CoA carboxylase fatty acid synthesis
pyruvate carboxylase gluconeogenesis, etc.
propionyl CoA carboxylase branched chain fatty acid metabolism
methylcrotinyl CoA carboxylase branched chain amino acid metabolism