Wk1 Adrenal Pharm Flashcards Preview

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Flashcards in Wk1 Adrenal Pharm Deck (11)
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1
Q

General effect of glucocorticoid meds:

A

suppress immune system

2
Q

Why are WBC’s elevated in glucocorticoid use?

A

neut’s get stuck in vessels – no chemotaxis

3
Q

Anti-allergic effect of GC’s:

A

inhibit histamine synthesis by mast cells

**no effect on receptors so still some effect from existing histamine

4
Q

Drug that has more mineralcorticoid effect

used to replace aldosterone

A

Fludrocortisone

**all others have greater glucocorticoid effect

5
Q

Potential risk in GC use in diabetics:

A

hyperglycemia

6
Q

Read slide…

A

28 – Dex test for cushing syndrome

7
Q

Glucocorticoid effect on cardiovascular system:

A

ionotropic

Na/H2O retention –> increased BP

8
Q

Tx for Cushing disease

inhibits cholesterol side chain cleavage

inhibits glucocorticoid and androgen synthesis

A

Ketoconazole

9
Q

Tx for Cushing disease

inhibits 11 beta hydroxylase in adrenal cortex

A

Metyrapone

10
Q

Dopamine effect on ACTH:

A

suppression via D2 receptors

Cabergoline (dopamine agonist) used to treat pituitary adenomas that secrete ACTH

11
Q

Last line for refractory ACTH secreting tumors

glucocorticoid receptor antagonist

A

Mifepristone