Wk3 Female Repro Drugs Flashcards Preview

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Flashcards in Wk3 Female Repro Drugs Deck (20)
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1
Q

Drug used to stimulate FSH secretion by blocking estrogen receptors:

A

clomiphine citrate

2
Q

MOA of clomiphine citrate:

A

estrogen receptor antagonist

block negative feedback

***increasing GnRH, LH, FSH release

3
Q

menotropin

A

FSH/LH analog

4
Q

urofolitropin

A

FSH/LH analog

5
Q

used to stimulate induction of ovulation by acting like LH

A

hCG

6
Q

Synthetic GnRH analog (agonist)

A

Leuprolide

7
Q

What happens INITIALLY if a NONpulsatile dose of Leuprolide is administered?

A

transient RISE in FSH/LH

followed by decrease

8
Q

What happens with pulsatile administration of Leuprolide?

A

increases FSH/LH –> follicle development

9
Q

GnRH ANtagonists:

A

ganiRELIX

cetroRELIX

10
Q

Pure estrogen antagonist in all tissue

A

Fulvestrant

11
Q

NONsteroidal

Reversible

Aromatase inhibitors

A

anasTROZOLE

leTROZOLE

12
Q

Steroidal

NONreversible

Aromatase inhibitor

A

Exemestane

13
Q

Main idea with aromatase inhibitors:

A

prevent estrogen production

used in estrogen+ cancers

14
Q

Progestin analog for contraception

A

Medroxyprogesterone acetate

15
Q

estrane analog for contraception

progesterone receptor agonist

A

Norethindrone

16
Q

gonane analog for contraception

progesterone receptor agonist

A

Levonorgestrel

17
Q

Progesterone agonist used as emergency contraceptive

cannot terminate pregnancy

A

Levonogestrel (Plan B)

18
Q

Selective Progesterone Receptor antagonist used to prevent ovulation (low dose) or terminate early pregnancy (high doses with misoprostol)

A

Mifepristone

19
Q

PGE1 analog

A

misoprostol

20
Q

Progesterone ANtagonist for emergency contraception

prevents or delays ovulation

A

Ulipristal acetate