Wk4 GI Immunity Flashcards Preview

GI > Wk4 GI Immunity > Flashcards

Flashcards in Wk4 GI Immunity Deck (27)
Loading flashcards...
1
Q

Cell responsible for immune tolerance of novel substances that may be important for nutrition:

A

T reg’s

2
Q

4 layers of GI defense:

A
  1. intraepithelial
  2. lamina propria
  3. Peyer’s patch
  4. Mesenteric lymph nodes
3
Q

aEB7 integrin

A

Intraepithelial lymphocyte chemotactic factor in vili

associated with E-cadherin

upper GI

4
Q

Intraepithelial lymphocyte of upper GI vili?

A

CD8+

5
Q

MADCAM1 (a selectin)

A

Upper GI

lamina propria chemotactic factor

associated with a4B7 integrin

6
Q

Peyers patch location:

A

lower GI

7
Q

Main regulator of inflammatory response:

A

NKkB

8
Q

Slide 19

A

lymphoid tissue

9
Q

IL for T regs?

A

IL-10

10
Q

lower GI cell that engulfs stuff:

A

M cell

11
Q

Adaptive immunity “training” location for ingested antigens:

A

Peyer’s Patches

Mesenteric LN’s

lower GI

Effector cells can enter circulation and distribute throughout the body

12
Q

Seven defense strategies of GI sys:

A
  1. Block entry into organism (most pathogens)
  2. Block entry into cell (bacteria, viruses)
  3. Prohibit spreading (most pathogens)
  4. Direct killing (most pathogens)
  5. Kill infected host cell (virus, intracellular bacteria, protozoa)
  6. expulsion (multicellular parasites)
  7. Nutrient depravations (bacteria, protozoa)
13
Q

Methods for blocking entry into organism:

A

tight junctions

cilia

mucin

Neutralizing antibodies

Anti-microbial peptides

Enzymes (lysozyme, PLA2 from paneth cells)

14
Q

Methods for blocking entry into cell:

A

AB’s bind pathogen – prevent adherence

Bacteria agglutinate

15
Q

Methods to prohibit spreading:

A

coagulation/vasoconstriction

neutralizing Ab’s

INFa/B (type 1)

  • increased MHC class 1
  • increased cell mediated cytotoxicity
16
Q

Methods for direct killing:

A

anti microbial peptides

bacterial permiability increasing proteins

lysozymes and stomach environment

complement

ROSs

RNSs (reactive nitrogen species)

17
Q

Cells producing a-defensins:

A

Neuts, NKs, Paneth

18
Q

Cells producing B-defensins:

A

Leukocytes, epithelial cells

19
Q

Method for killing infected host cell:

A

INFa/B (type 1)
-induces MHC1

NKs

NK T cells

Cytotoxic T-lymphs

Antibody dependent cellular cytotoxicity (ADCC)

20
Q

Methods for expulsion:

A

IgE

Vasoactive substances
-leukotrienes, PGs, histamines

Mucous

SM contraction

cilia

21
Q

Methods for nutrient depravation:

A

Fe removed by lactoferrin

Manganese removed by NRAMP

Zinc removed by ZIP/ZnT

22
Q

Dendrites that reach out and sample lumen?

A

CD19 - ?

23
Q

Pro inflammatory cytokines?

A

INF-gama

TNF-a

IL-12

24
Q

anti-inflammatory cytokines?

A

IL-10 (T regs)

IL-1ra

25
Q

Type of inflammation with:

Th1
IFN-gama
M1 (angry) mac's
IgG, sIgA
CTL's
NKs
A

acute

26
Q

Type of inflammation with:

Th2/Th17
IL-4, IL-17
M2 mac's
IgE
Eosinophils
Basophils
A

Chronic

27
Q

try to figure out slide 63

A

it’s on the test