Zoonotic Viral Diseases Flashcards

1
Q

Over half of all human pathogens are ___________.

A

zoonotic, meaning they have an animal reservoir

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2
Q

Most zoonotic diseases are _____________.

A

RNA viruses

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3
Q

Hantavirus is also called ______________.

A

sin nombre virus

Think of a nameless ghost HAuNTing people.

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4
Q

Which three viruses are only transmitted from animals to humans (i.e., those that don’t have human-to-human transmission)?

A
  • Rabies
  • West Nile
  • Hantavirus
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5
Q

There are unique strains of rabies in skunks, bats, foxes, dogs, and raccoons, but fortunately _______________.

A

the rabies treatment is effective for all strains

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6
Q

The incubation period of rabies is ______________.

A

quite long (up to one year!)

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7
Q

What are the two forms of rabies?

A
  • Encephalitic (80%): brainstem dysfunction

* Paralytic (20%): quadriplegia

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8
Q

True or false: rabies encephalitis presents with viremia.

A

False. Rabies exists in nerves.

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9
Q

How effective is rabies treatment?

A

Extremely… no documented failures since the 1970s.

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10
Q

The primary mode of transmission to humans for Hantavirus is ______________.

A

aerosolized rodent urine

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11
Q

What signs and symptoms are highly suggestive of Hantvirus?

A
  • Severe lower back and leg pain
  • Neutrophilia
  • Low platelet count
  • Elevated LDH and AST
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12
Q

Name three viruses that are mostly animal-to-human transmission but can have human-to-human transmission?

A
  • Filoviruses
  • Arenaviruses (like Lassa)
  • Hendra and Nipah (both in the family Paramyxovirus)
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13
Q

_____________ has a filamentous morphology.

A

Filoviruses

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14
Q

The 2014 –2016 outbreak of Ebola caused how many deaths?

A

20,000

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15
Q

The best treatment for Ebola is ______________.

A

IV fluid resuscitation, treatment of other infections, and oxygen

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16
Q

Give an example of a virus that originated in animals but is now strictly human-to-human.

A

HIV

17
Q

Which animals harbor most of the rabies exposures?

A

Raccoons (32%), bats (27%), and skunks (24%)

18
Q

Ebola has been shown to persist in the _______________.

A

CNS, eye, semen, and amniotic fluid

19
Q

Which kind of HIV is present only in west Africa?

A

HIV-2 (while HIV-1 is more widespread)