8: Breast CPC / MDT Flashcards

1
Q

Apart from increased or decreased density, what are some common mammography findings in breast cancer?

A

Microcalcifications

Necrosis

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2
Q

In which type of breast cancer is necrosis commonly seen?

A

In-situ cancers

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3
Q

Necrosis may be found within which breast structures?

A

Ducts

suggesting a ductal carcinoma

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4
Q

What other area, apart from the breasts, should be examined and imaged in suspected breast cancer?

A

Axilla

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5
Q

What type of mammogram is used to help insert a biopsy needle for a breast biopsy?

A

Stereotactic mammogram

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6
Q

Which type of core biopsy is commonly used to get breast cancer cells?

A

Vacuum assisted core biopsy

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7
Q

What can you do to an biopsy sample to confirm you’ve got the right tissue?

A

X-ray it

looking for the features you saw on the mammogram

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8
Q

How do you determine the grade of a ductal carcinoma in situ?

A

Compare tumour cells to the normal breast cells around them

Poorly differentiated (i.e wildly different from parent cells) is a sign of high grade and a poor prognosis

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9
Q

Which imaging is used to aid breast surgery?

A

Mammography

stereotactic again, with a wire

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10
Q

Which imaging is used to determine if the whole extent of a breast tumour has been removed?

A

X-ray

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11
Q

Why isn’t a sentinel node biopsy required for in-situ breast cancers?

A

Hasn’t breached the basement membrane

So by extension cannot have breached the lymph nodes

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12
Q

How can the risk of recurrence be reduced post-breast surgery?

A

Adjuvant radiotherapy

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13
Q

Distortion is a feature of (low grade / high grade) cancers.

A

low grade

AND radial scars

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14
Q

Which type of image-guided biopsy is the most comfortable for a patient?

A

USS

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15
Q

What histological feature would you see on radial scars?

A

“Architectural distortion”

i.e everything’s dodgy because there’s sclerosis

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16
Q

What is meant by the

a) stage
b) grade

of a tumour?

A

a) Local invasion

b) Degree of differentiation

17
Q

Which measure is used to estimate breast cancer prognosis?

A

Nottingham Prognostic Index

Any number below 3 is excellent

18
Q

Is adjuvant hormonal therapy indicated for women with very low grade breast cancers?

A

No

If the prognosis is excellent then adjuvants are just extra side effects

19
Q

What scan is used to rule out metastatic disease in high grade invasive breast cancers?

A

CT scan

head chest pelvis bones etc.

then MRI scan to monitor the progression of disease and response to treatment

20
Q

Transtuzumab is often given alongside which treatment?

A

Chemotherapy

21
Q

What are the treatment options for breast cancer?

A

Surgery (breast conserving or radical) +/- axilla

Radiotherapy +/- axilla

Chemotherapy

Hormonal therapy

Herceptin