Cancer

Question 1

Spindle cell tumour
Produces osteoid
Associated with pagets disease

Answer 1

Osteosarcoma

Question 2

Chemicals in tobacco smoke

Answer 2

polycyclic hydrocarbons
aromatic amines
phenols
nickel
cyanates

Other risk factors:
Asbestos
nickel
chromates
radiation 
atmospheric pollution
(genetics)

Question 3

Where does lung cancer metastasise to?

Answer 3

Nodes
Liver
Brain
Bones

Question 4

PTH

Answer 4

Squamous cell carcinoma

Question 5

ACTH

Answer 5

Small cell cancer

Question 6

Keratinising lung cancer?

Answer 6

Squamous cell carcinoma - this is like normal skin cells hence why they are keratinising

Question 7

Gland forming

Answer 7

Adenocarcinoma

If gland forming then mucin! :)

Question 8

P63

Answer 8

Squamous cell carcinoma

Question 9

Thyroid transcription factor (TTF-1)

Answer 9

Adenocarcinoma and small cell

Question 10

Treatment for small cell vs. non-small cell

Answer 10

Small cell : chemo (works v. well but only for short time :( )
Non small cell: surgery

Question 11

K-ras mutation associated with?

Answer 11

Adenocarcinoma (smoking related)

• East Asia = adenocarcinoma in NOT smoking related
• EGFR mutation

Question 12

Gefitinib

Answer 12

Tyrosine kinase inhibitor

-can work in EGFR mutation adenocarcinoma (non-smokers)

Question 13

Neuroendocrine neoplasm of low malignancy?

Answer 13

Carcinoid

Question 14

Adenoid cystic carcinoma

Mucoepidermoid carcinoma

Answer 14

Bronchial gland neoplasm

Question 15

Cavitates, with central necrosis

Answer 15

Squamous cell carcinoma (most common type)

Keratinising

Question 16

Most common lung cancer type in non-smokers?

Answer 16

Adenocarcinoma

• gland forming
• often at peripheries

Question 17

Arises from neuroendocrine cells? Often secretes POLYPEPTIDE HORMONES

Answer 17

Small cell lung cancer