Chapter 6:: Skin Glands: Sebaceous, Eccrine, and Apocrine Glands Flashcards Preview

Derma 9 > Chapter 6:: Skin Glands: Sebaceous, Eccrine, and Apocrine Glands > Flashcards

Flashcards in Chapter 6:: Skin Glands: Sebaceous, Eccrine, and Apocrine Glands Deck (11):
1

The periphery of the sebaceous gland is a basal cell layer composed of small, _____, _______, ________.

cuboidal, nucleated, highly mitotic sebocytes

2

A sebaceous gland associated with a hair follicle is termed a _______.

pilosebaceous unit

3

The hairs associated with these large glands are often tiny, and the total structure is more specifically termed ______, being a pilosebaceous unit variant, the other two being the ______ and the ______.

sebaceous follicles, terminal hair follicle, vellus hair follicle

4

The earliest known signal necessary for sebaceous gland development is _____

SOX9

5

Antagonizing _______signaling constitutes an impor- tant prerequisite for normal sebaceous differentiation in postnatal skin tissue.

Wnt–β-catenin

6

The sebaceous glands exude lipids by disintegration of entire cells, a process known as _________.

holocrine secretion

7

Sebaceous glands require ________ stimulation to produce significant quantities of sebum.

androgenic

8

The weak adrenal androgen, ___________, is probably a significant regulator of sebaceous gland activity through its conversion to testosterone

dehydroepiandros- terone sulfate (DHEAS)

9

___________ is the most potent pharmacologic inhibitor of sebum secretion.

Isotretinoin

10

___________ may reduce sebaceous lipid synthesis and as such may be useful in the treatment of acne.

PPAR-α agonists and PPAR-γ antagonists

11

The average transit time of sebaceous gland cells from formation to discharge, has been calculated as______days in the human gland, with 4 to 7 days in undifferentiated and 14 to 25 in differentiated lipid- producing cells.

The synthesis and discharge of the lipids contained in the sebaceous cells require more than 1 week. The size of sebaceous glands ______________ with age.

7.4

increases