DTP Aspirin

Question 1

Drug class for aspirin

Answer 1

Anti platelet

Question 2

Pharmacology for aspirin

Answer 2

Inhibits COX (inhibits platelet aggregation)
Reduces thrombaxane A2 synthesis for the life of the platelet.
Prevents platelets aggregating on exposed collagen fibres at the site of vascular injury.

Question 3

Metabolism of aspirin

Answer 3

Converted to salicyclic acid in many tissues
Primarily the GI mucousa and liver
Excreted by the kidneys.

Question 4

Indications for aspirin

Answer 4

1. ACS

2. Acute cardiogenic pulmonary oedema

Question 5

Contraindications for aspirin

Answer 5

Psychostimulant associated chest pain

Question 6

Precautions of aspirin

Answer 6

1. Suspected aortic aneurysm or other condition requiring surgery
2. Hx of GI bleed or peptic ulcers
3. pregnancy
4. Pts on concomitant anticoagulant therapy except for clopidogrel

Question 7

Side effects of aspirin

Answer 7

Nausea/vomiting
NSAID induced bronchospasm
Epigastric pain/discomfort
GI Bleeding
Gastritis

Question 8

Presentation of aspirin

Answer 8

300 mg tablet

Question 9

Duration of Aspirin

Answer 9

anti platelet action lasts 7-10 days

Question 9

Onset of aspirin

Answer 9

10 mins variable

Question 10

Half life of aspirin

Answer 10

300- 650 mg = 3.2hrs

Question 11

Aspirin schedule

Answer 11

S2 therapeutic poisons

Question 12

Dose for aspirin

Answer 12

300 mg tablet single dose PO

Question 13

Special notes for aspirin

Answer 13

1. Should be administered following initial dose of GTN in ACS or cardiogenic APO.
2. Indicated in ACS or cardiogenic APO even if pt is pain free
3. Pt had < 300 mg of aspirin w/in 24 hrs should be administered a dose = 300-450 mg daily dose.