FUROSEMIDE (Lasix®)

Question 1

Generic/Trade Name

FUROSEMIDE

Answer 1

Lasix®

Question 2

Generic/Trade Name

Lasix®

Answer 2

FUROSEMIDE

Question 3

FUROSEMIDE (Lasix®)

Drug Classification:

Answer 3

Loop Diuretic

Question 4

FUROSEMIDE (Lasix®)

Mechanism of Action:

Answer 4

Furosemide reversibly binds to chloride binding site on Na+/2Cl-/K+ cotransporter found on the luminal surface of the thick ascending limb of the loop of Henle ⇒
inhibits sodium and chloride reabsorption in the kidneys, thus impacting the osmotic gradient and reducing water reabsorption in the descending limb; causes venous dilation and subsequently reduces preload

Question 5

FUROSEMIDE (Lasix®)

Pharmacokinetics

Answer 5

Onset of Action = 5-10 minutes vasodilation, 5-30 minutes, diuresis

Peak Effects = 30 minutes vasodilation, 20-60 minutes diuresis

Duration of Effect = 2 hours vasodilation, 6 hours diuresis

Half-Life = 30 minutes

Question 6

FUROSEMIDE (Lasix®)

Indications/Field Use:

Answer 6

• CHF
• Pulmonary Edema

Question 7

FUROSEMIDE (Lasix®)

Contraindications:

Answer 7

• Caution with sulfa allergies
• Caution with renal failure
• Pregnancy unless life threatening

Question 8

FUROSEMIDE (Lasix®)

Side Effects/Adverse Reactions:

Answer 8

• HA
• dizziness
• hypotension
• volume depletion
• potassium depletion
• dysrhythmias
• diarrhea
• N+V

Question 9

FUROSEMIDE (Lasix®)

ADULT DOSE:

Answer 9

• 40mg slow IV, IO;
• if Pt. takes Lasix daily incl. today, give their dose,
• if Pt. takes Lasix but didn’t today, double their dose

Question 10

FUROSEMIDE (Lasix®)

PEDI DOSE:

Answer 10

• 0.5-1mg/kg slow IVP
• not for children under 12

Question 11

FUROSEMIDE (Lasix®)

Precautions:

Answer 11

• Note LS and BP before and after
• Protect from light
• May cause dehydration

Question 12

FUROSEMIDE (Lasix®)

Drug-Drug Interactions:

Answer 12

• May cause additive effects and/or electrolyte imbalance if given with other
  diuretic
• NSAIDs may antagonize effects of Lasix