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Hematology-Oncology Exam 2 > Lymphoma > Flashcards

Lymphoma Flashcards

1
Q

What is the 7th most common cause of cancer death

A

Lymphoma

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2
Q

Lymphoma has a predominance for M/F?

A

Males

Although females are more common for follicular lymphoma

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3
Q

At what age can lymphoma occur

A

all ages

avg age is 42

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4
Q

3% of what pts will develop lymphoma

A

AIDS pts

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5
Q

Name two probable contributors of why there is an increase in incidence of AIDS pt developing lymphoma

A

phenoxyherbicide use and aging of pop.

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6
Q

80% of lymphomas are from what origin

A

B-cell

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7
Q

What pathogen is associated with Hodgkin’s

A

EBV

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8
Q

What is the gold standard for lymphoma diagnosis

A

excisional biopsy

needle biopsy can be used to determine if a mass is lymphomatous BUT to see the histo of it excisional is best

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9
Q

What 3 things do clinicians and pathologist have to communicate clearly about

A
  1. certainty of diagnosis
  2. quality of material available for interpretation
  3. clinical course going to be taken
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10
Q

What is the most characteristic feature of B-cell lymphoma

A

painless LN enlargement

can have a “rubbry” feel

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11
Q

What is the predominant classification of lymphoma

A

nodal presentation

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12
Q

what is nodal presentation

A

invovlemnt of LN and other lymphoid structures like the liver and spleen

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13
Q

what is the extra-nodal presentation

A

rarer and important to recognize bc treatment may be site specific

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14
Q

the Ann Arbor staging stages what?

A

Hodgkins Disease

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15
Q

Ann Arbor staging is …

A

limited and extensive

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16
Q

Why is Ann Arbor staging used

A

to differentiate btwn available treatment options

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17
Q

what often has microscopic disease at distant sites demonstrated by subsequent relapse

A

clinically localized low grade lymphoma

18
Q

what has a greater probability of being pathologically localized

A

higher grade clinically localized lymphoma

it can also turn widespread but if diagnosed quickly and treated it can be cured

19
Q

what is the main reason staging procedures are chosen

A

to guide therapy selection

20
Q

what was the main criteria of the NCI working formulation classifcation

A

morphologic

21
Q

which classification system utilized immunophenotypic and genetic data

A

REAL and WHO

22
Q

what is the translocation for Follicular lymphoma

A

t(14,18)

23
Q

what is the translocation for Burkitt’s lymphoma

A

t(8,14)

24
Q

what is the translocation for mantle cell lymphoma

A

t(11,14)

25
Q

what is the survival rate for mantle cell lymphoma

A

3-5 years

26
Q

what are the diagnostic markers for mantle cell

A

sIgM+ IgD+
CD19,20,79a+

CD5+ 10+/- 11c- 23- 43+.

27
Q

what is the general main marker for indolent lymphoma

A

KI67

28
Q

Treatment he bolded for mantle cell

A

Ibrutinib

29
Q

What type of lymphoma is follicular center

A

generally indolent with widespread disease

30
Q

What are the markers for follicular center

A

sIgM+/- IgD+ /-
CD19,20,79a+

CD5- 10+ 11c- 23-/+ 43-.

31
Q

Marginal zone B-cell lymphoma: extra-nodal ?

A

Low-grade B-cell Lymphoma of MALT type, ( ± monocytoid B cells)

32
Q

Marginal zone B-cell lymphoma: nodal ?

A

( ± monocytoid B cells)

33
Q

What disease are Marginal zone B-cell lymphoma associated with?

A

autoimmune disease related (Sjogren’s, Hashimoto’s),

helicobacter related gastric MALT lymphoma.

34
Q

what are the markers for mantle cell

A

sIgM+/- IgD+ /-
CD19,20,22,79a+

CD5- 10- 11c+/- 23- 43-/+

35
Q

What genetic defect is associated with mantle cell

A

trisomy 3

36
Q

what kind of lymphoma is mantel cell

A

indolent and localized
cured with local treatment
can use Ab to treat h. pylori in gastric MALT lymphoma

37
Q

what is used for advanced NHL

A

CHOP with 3 intensive chemo

38
Q

what is used in relapses of chemo-sensitive NHL

A

Autologous Bone marrow transplant (Auto-BMT)

39
Q

What is the only approved treatment for low grade lymphoma

A

Rituxan -monoclonal Antibody therapy

targets CD20

40
Q

what were rituxan’s side effects

A

fever, chills

occurs mainly on first infusion

Hematology-Oncology Exam 2 (15 decks)

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