Peripheral Neuropathy

Question 1

symptoms of large motor fibre neuropathy

Answer 1

weakness, unsteadiness, wasting
reduced power
normal sensation
absent reflexes

Question 2

symptoms of large sensory fibre neuropathy

Answer 2

numbness, pasaesthesia, unsteadiness
normal power
vibration and joint position sense decreased
absent reflexes

Question 3

symptoms of small fibre neuropathy

Answer 3

pain and dyesthesia (pain on touch)

normal power and reflexes pin prick and temp reduced

Question 4

symptoms of autonomic neuropathy

Answer 4

dizziness - postural hypotension

nausea/vomiting - gastroparesis

Question 5

foot drop and high stepping gait are signs of neuropathy in the

Answer 5

common fibular (peroneal) nerve

Question 6

wrist drop is due to a neuropathy in

Answer 6

radial nerve

Question 7

claw hand is due to a neuropathy in

Answer 7

ulnar nerve

Question 8

what is pseudoathetosis

Answer 8

loss of proprioception usually seen in the hands

Question 9

clinical signs in pseudoathetosis

Answer 9

no vibration sense in hands
cerebellar signs (but with loss of proprioception)
odd movements of hands

Question 10

what is radiculopathy

Answer 10

damage to nerve root

Question 11

most common area of radiculopathy

Answer 11

spine

Question 12

clinical features of radiculopathy

Answer 12

pins and needles

loss of reflexes

Question 13

what is plexopathy

Answer 13

problem affecting brachial or lumbar plexus

Question 14

common cause of plexopathy

Answer 14

trauma

Question 15

common sign of plexopathy

Answer 15

distal and proximal asymmetric weakness

Question 16

damage to 2 or morenerves is called

Answer 16

mononeuritis multiplex

Question 17

how many nerves are affected in mononeuropathy

Answer 17

one

Question 18

how are the nerves damaged

Answer 18

axonal loss

demyelination

Question 19

acute demyelinating condition

onset is days-weeks

Answer 19

guillaine barre syndrome

Question 20

clinical manifestation of guillaine barre syndrome

Answer 20

stars with tingling limbs and pain
quadaplegia in 2 weeks
ventilation problems

Question 21

association with guillaine barre syndrome

Answer 21

post campylobacter infection

Question 22

common cause of death in guillaine barre syndrome

Answer 22

respiratory distress/failure

Question 23

treatment for guillaine barre

Answer 23

immunoglobulin infusion or plasma exchange

Question 24

most common mutation in hereditary neuropathies

Answer 24

CMT1a

Question 25

clinical features of hereditary sensory motor neuropathy type 1 (most common type)

Answer 25

champagne bottle leg sign 
hand deformities 
bones don't form properly 
pes cavus (claw foot)

Question 26

mode of inheritance of HSMN type 1

Answer 26

autosomal dominant