Rectal Cancer

Question 1

What did the German Rectal Cancer Study group show?

Answer 1

Neoadjuvant prolonged course RT with 5FU-based chemotherapy for T3+/N0-2 rectal cancer

Local Recurrence rates and toxicities are more favorable with neoadjuvant ChemoRT
OS similar for neoadjuvant CRT cf postop CRT

Question 2

When should transanal excision should be considered?

Answer 2

Select patients with:

• Early stage Rectal CA
• small real CA

Question 3

Is adjuvant therapy needed after transanal resection?

Answer 3

NO.

After transanal resection of appropriately selected patients with early-stage rectal cancer, no further therapy required

Question 4

What is the standard therapy for early localized squamous Ca of the anus?

Answer 4

ChemoRT with 5FU & Mitomycin
- a/w excellent cure rates

Salvage APR reserved for recurrent anal cancer