Signal Transduction Modulators Flashcards
Explain how hormonal treatment of cancer occurs
The cancer cell is mutated via uncontrolled cell proliferation using activated signaling pathways
What are progestational drugs used in the management of
Endometrial carcinoma
How do progestin drugs work
By reducing the production of hormones that stimulate the neoplastic endometrium
What determines growth of malignant changes in the breast and prostate
Hormones
What electrolyte imbalance is associated with androgen or estrogen therapy-and how do you treat it
Hypercalcemia-adequate hydration to facilitate renal excretion of calcium
prostate cancer growth is stimulated by androgens- what slows the growth of ca
Orchiectomy-removal of prostate
and/or
Estrogens
Eventually the prostatic tumor becomes insensitive to lack of androgens or presence of estrogen- what does this mean
The undifferentiated cells favor the emergence of cell types that no longer depend on androgens for their growth
Malignant tissues that are responsive to estrogen must contai what
Receptors for the hormone
What are antiestrogens such as tamoxifen used for
The treatment of breast cancer
Because tamoxifen is antiestrogenic in breast and ovarian tissues but estrogenic in the uterus, liver, and bone what undesirable estrogen effects occur
DVT
ENDOMETRIAL CANCER
EARLY MENOPAUSE SYMPTOMS
Name two other seemly random side effects of tamoxifen
Lowers plasma cholesterol
Increases bone density
Is tamoxifen beneficial to cancers that do not express hormone receptors
No
How do Antiandrogens work
Competitive antagonist of the interactions between androstenedione and androgen receptors
What is the anti androgen flutamide used for
Hormone dependent prostate ca
Androgenic blockade results in
Feminizing side effects in men, gynecomastia, hot flashes, loss of facial hair
