Translocations in Hematological Malignancies

Question 1

t(14;18)(q32;q21)

Answer 1

BCL2. B-cell leukemia, follicular lymphoma. Southern blotting, PCR.

Question 1

(9;22)(q34;q11)

Answer 1

Philadelphia chromosome. Chronic myelogenic leukemia, adult acute lymphoblastic leukemia. BCR-abl. Southern blotting, rtPCR, qPCR better.

Question 1

<p class=”large” style=”text-align:center”;>t(15;17)(q22;q11.2-q12)</p>

Answer 1

<p class=”large” style=”text-align:center”;>PML/RARA. Found in promyelocytic leukemia. Also indicative of retinoids acid treatment. PCR or RTPCR.</p>

Question 1

t(11;14)(q13;q32)

Answer 1

BCL1. Associated with mantle cell lymphoma. PCR.

Question 1

t(8;14)(q24;q11)

Answer 1

c-myc. Burkitt’s lymphoma. Southern blot, Northern blot, FISH.