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Clinical Pharm > Vasopressors/paralytics > Flashcards

Vasopressors/paralytics Flashcards

1
Q

Phenylepherine MOA

A

Pure Alpha 1

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2
Q

Phenylepherine infusion dose range

A

20-200 mcg/min

0.15-1.0 mcg/kg/min

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3
Q

Phenylepherine bolus dose

A

40-100 mcg

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4
Q

Phenylepherine considerations

A

Increased SVR

Reflex bradycardia

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5
Q

Ephedrine MOA

A

Alpha 1, Beta 1
Indirect>direct
Causes NE release

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6
Q

Ephedrine bolus dose

A

5-25 mg

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7
Q

Ephedrine considerations

A

Increase HR

Tachyphylaxis

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8
Q

Epinephrine MOA

A

Alpha 1
Beta 1
Beta 2

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9
Q

Epinephrine infusion dose range

A

1-20 mcg/min

0.01-0.3 mcg/kg/min

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10
Q

Epinephrine bolus dose

A

10-500 mcg

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11
Q

Norepinephrine MOA

A

Alpha 1

Beta 1

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12
Q

Norepinephrine infusion dose

A
  1. 5-30 mcg/min

0. 01-0.3 mcg/kg/min

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13
Q

Dopamine MOA

A

beta 1
Beta 2
Dopamine
Alpha 1

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14
Q

Dopamine infusion dose

A

1-20 mcg/kg/min

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15
Q

Vasopressin MOA

A

V1 SM

V2 CD

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16
Q

Vasopressin infusion dose

A

0.01-0.1 units/min

1-6 units/hr

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17
Q

Vasopressin bolus dose

A

1-10 units

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18
Q

Milrinone MOA

A

PDE III inhibitor

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19
Q

Milrinone infusion dose

A

0.375-0.75 mcg/kg/min

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20
Q

Milrinone bolus dose

A

50 mcg/kg over 10 minutes

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21
Q

Milrinone considerations

A

Increase CO and contractility

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22
Q

Phenylephrine concentration

A

100 mcg/mL

40 mcg/mL

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23
Q

Phenylephrine therapeutic effect

A

Increase SVR
Increase stroke volume
Increase venous return

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24
Q

Phenylephrine adverse effects

A

Reflex bradycardia

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25
Q

Phenylephrine clearance

A

Hepatic metabolism

Renal elimination

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26
Q

Ephedrine concentration

A

Dilute to 5 or 10 mg/ml

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27
Q

Ephedrine therapeutic effect

A

Increase HR

Increase venous return

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28
Q

Ephedrine adverse effects

A

Increase MVO2

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29
Q

Ephedrine clearance

A

Renal elimination

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30
Q

Epinephrine concentration

A

1: 10,000 = 100 mcg/mL
1: 1,000 = 1 mg/mL

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31
Q

Epinephrine therapeutic effect

A 
Increase SVR
Increase HR
Increase contraction
Increase vascular resistance
Bronchodilaton
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32
Q

Epinephrine adverse effects

A

Increase glucose

Arrhythmogenic

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33
Q

Epinephrine clearance

A

MAO/COMT

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34
Q

Norepinephrine concentrations

A

4 mg/250 mL D5W

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35
Q

Norepinephrine adverse effects

A

Constrict microvascular

Oliguria

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36
Q

Norepinephrine clearance

A

MAO/COMT

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37
Q

Dopamine concentration

A

4 mg/250 mL D5W

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38
Q

Dopamine dose vs. MOA

A

5-10 B1>a1

10-20 a1>B1

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39
Q

Dopamine adverse effects

A

Tachyphylaxis

Oliguria

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40
Q

Dopamine MOA

A

MAO/COMT

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41
Q

vasopressin concentration

A

1 unit/mL

20 Units/mL in 20 mL NaCl

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42
Q

Vasopressin therapeutic effect

A

Increase SVR

Increase V1 smooth muscle

43
Q

Vasopressin adverse effects

A

Pulmonary edema

GI ischemia

44
Q

Vasopressin half life

A

10-20 min

45
Q

Vasopressin clearance

A

Renal elimination

46
Q

Milrinone concentration

A

50 mg/250 mL

47
Q

Milrinone therapeutic effect

A

Increase contractility
Increase CO
Lusitropic
Decrease PVR

48
Q

Milrinone adverse effects

A

Decrease BP

Ventricular arrythmias

49
Q

Milrinone clearance

A

Hepatic metabolism

Renal elimination

50
Q

Rocuronium class

A

Steroid

51
Q

Rocuronium intubating dose

A

0.6-1.2 mg/kg

52
Q

Rocuronium bolus dose

A

5-10 mg

53
Q

Rocuronium RSI dose

A

1.2 mg/kg

54
Q

Rocuronium concentration

A

10 mg/ml

55
Q

Rocuronium onset

A

60-90 seconds

56
Q

Rocuronium duration

A

30-60 minutes

57
Q

Rocuronium considerations

A

Anaphylactoid

No hemodynamics changes

58
Q

Rocuronium clearance

A

60% hepatic

30% renal

59
Q

Rocuronium half life

A

1-2 hours

60
Q

Vecuronium class

A

Steroid

61
Q

Vecuronium intubating dose

A

0.1 mg/kg

62
Q

Vecuronium bolus dose

A

1-4 mg

63
Q

Vecuronium infusion dose

A

0.08-1.2 mcg/kg/min

64
Q

Vecuronium concentration

A

1 mg/mL

65
Q

Vecuronium onset

A

2-4 minutes

66
Q

Vecuronium duration

A

30-60 minutes

67
Q

Vecuronium considerations

A

Anaphylactoid

No hemodynamic changes

68
Q

Vecuronium clearance

A

Hepatic 50%

Renal 50%

69
Q

Pancuronium class

A

Steroid

70
Q

Pancuronium intubating dose

A

0.1 mg/kg

71
Q

Pancuronium bolus dose

A

1-2 mg

72
Q

Pancuronium special considerations

A

Vagolytic

73
Q

Pancuronium concentration

A

1 mg/ml

74
Q

Pancuronium onset

A

2-4 min

75
Q

Pancuronium duration

A

30-60 min

76
Q

Pancuronium adverse effects

A

Increase HR, BP, CO

77
Q

Pancuronium clearance

A

90% renal

78
Q

Atracurium class

A

BISQ-AB

79
Q

Atracurium intubating dose

A

0.5 mg/kg

80
Q

Atracurium bolus dose

A

1-4 mg

81
Q

Atracurium infusion dose

A

0.08-1.2 mcg/kg/min

82
Q

Atracurium concentration

A

10 mg/ml

83
Q

Atracurium onset

A

2-4 min

84
Q

Atracurium duration

A

30-60 minutes

85
Q

Atracurium clearance

A

Hofmann elimination

Plasma esterases

86
Q

Cistracurium class

A

BISQ-AB

87
Q

Cisatracurium intubating dose

A

0.15-0.2 mg/kg

88
Q

Cisatracurium bolus dose

A

1-4 mg

89
Q

Cisatracurium considerations

A

Renal/hepatic dysfunction

90
Q

Cisatracurium concentration

A

2 mg/ml

91
Q

Cisatracurium onset

A

2-4 min

92
Q

Cisatracurium duration

A

30-60 minutes

93
Q

Atracurium adverse effects

A

Increase HR
Decrease SVR
Histamine release

94
Q

Cisatracurium clearance

A

Hofmann elimation

Plasma esterases

95
Q

Cisatracurium adverse effects

A

None

96
Q

Suxx class

A

Depolarizing

97
Q

Suxx intubating dose

A

IV: 0.5-1.5 mg/kg
IM: 2-3 mg/kg

98
Q

Suxx contraindications

A 
MH
DMD
Burns
Rhbdo 
Paralysis
99
Q

Suxx dose used to treat laryngospasm

A

2-3 mg/kg

100
Q

Suxx concentration

A

20 mg/ml

101
Q

Suxx onset

A

30-60 seconds

102
Q

Suxx duration

A

5-10 min

103
Q

Suxx adverse effects

A

Bradycardia
Hyperkalemia
Myalgias
Increased ICP, IGP

104
Q

Suxx clearance

A

Plasma pseudocholinesterase

Clinical Pharm (10 decks)

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