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K Sun
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Decks in this class (8)
Innate Immunity
Synonyms pmn 1,
Selectin 2,
Integrins pmn 3
38
cards
MHC and Antigen Presentation
0
cards
Adaptive Immunity: Antigen Recognition
Repertoire 1,
T cell negative selection 2,
T cell positive selection 3
23
cards
T-Cell Activation
Processes:
1. antigen recognition/ costimulation
a. antigen recognition/ TCR signaling
i. CD3: ITAM signal transduction
ii. epsilon- ITAM signal transduction
iii. CD4/ CD80 Lkc signal transudction
b. costimulators-
i. CD28 receptor on Tcells
ii. CD40 L
iii. co-inhibitors: CTLA-4 and PD-1
c. adhesion molecules-
2. Pathways
1. PLCA1- calcium
2. PLCA- DAG
3. GTP/ RAS
4. PI-3 Kinases
3. Differentiation
43
cards
T-Cell Effector Mechanisms
Processes
1. Homing to Lymph Tissue, High Endothelial Venules
i. Rolling Adhesion: L-selectin
ii.. Rolling Adhesion: CCR7
iii. Stationery Adhesion: general integrins (LFA-1)
Diapedesis: S1P leads a cell out of lymph nodes
2. Homing to infected peripheral tissue
i. Rolling Adhesion: E and P selectin ligand
ii. Stationery Adhesion: LFA-1 and VLA-4 (integrins)
iii. diapedesis
3. TH1 Response- classic macrophages activation
a. macrophages present antigen
b. CD4 cells express CD40 li
32
cards
Humoral Effector Mechanisms (Intervention)
1. antibody mediate opsonization (IgG)
2. NK cytotoxicity (IgG)
3. Mast Cell Reactions (IgE)
4. Classical Complement Activation (IgG&M)
5. Mucosal/ Neonatal Immunity (IgA; G)
32
cards
Humoral Immunity: Antigen Recognition (Detection)
Humoral Immunity: Detection
1. FcRn sequestration
2. Oposonization
3. Cytotoxicity
4. IgE and helminths
5. Complement Pathways
a. classic pathway
b. alternative pathway
c. lecithin pathway
6. Complement Effects
a. f(x): antimicrobial, B-activation
b. regulation: DAF and C1 inhibitor
23
cards
Tumor Immunobiology
Tumor antigens driver mutations 1,
Tumor antigens passenger mutation 2,
Tumor antigens normal proteins 1 3
11
cards
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Immunology
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