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Jenna Tapper
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Decks in this class (20)
E1 L1: IV Bolus
Pk definition,
Adme,
Two major elimination pathways
33
cards
E1 L2: Drug Distribution
Passive diffusion properties,
Transcellular junctions,
P
38
cards
E1 L3: Constant Rate Regimen
R0,
K,
K a
4
cards
E1 L4: Oral Dosing
3 routes of admin,
Iv bolus,
Drug accumulates in the body unti...
33
cards
E1 L5: Hepatic Drug Metabolism
Oxygen rich blood flows into the ...,
Blood flows out of the liver through,
Nutrient rich blood coming from t...
42
cards
E1 L6: Bioavailability and Clearance 1
Fraction of the administered dose...,
The value of f is termed,
Bioavailability units and range
34
cards
E1 L7: Bioavailability and Clearance 2
What determines eh,
Eh,
Max organ clearance values are eq...
38
cards
E1 L8: Bioavailability and Clearance 3
Fa,
Eg,
Bioavailability f equation
13
cards
E1 L9: Bioavailability and Clearance 4:
When fe is 0,
What directional changes in auciv...,
What directional changes in aucpo...
46
cards
Ex 2. L1: Multiple Dosing Regimen
Infusion vs multiple dosing,
Do you reach steady state at the ...,
Principles of drug accumulation i...
17
cards
Ex 2. L2: Multi Dose II
Dosing regimen steps,
1 know the target concentration r...,
2 determine the max dosing interv...
7
cards
Ex. 2 L3: Multicompartmental analysis
Multicompartment,
2 compartment pk model aka,
One compartment model
23
cards
Ex. 2 L4: Noncompartmental Analysis
Noncompartmental analysis,
Noncompartmental variables,
Clearance and compartmental analysis
22
cards
Ex 2. L5: Metabolite Kinetics
Importance of metabolite pk,
I,
Contribution of metabolites to dr...
42
cards
Ex. 2 L6: Drug Transporters
Types of drug transport,
Uptake and efflux transport use,
Role of drug transporters in drug...
39
cards
Ex. 2 L7: PK of Biological drugs
What are bilogics,
Biologics examples,
Mabs
42
cards
Ex. 2 L8: Nonlinear PK
Nonlinear intro,
Absorption mechanisms,
Example drugs saturable transport...
24
cards
Ex. 2 Practice Questions
L1 t f higher dose is expected to...,
L1,
L1 when you switch dosage regimen...
35
cards
Final L1 - PKD 1
Pharmacodynamics definition,
Pharmacodynamics,
Importance of pk pd
30
cards
Final L2 - PK in Renal disease
Ideal marker of gfr,
Assessment of kidney function,
Cg
11
cards
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Kinetics
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