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Hibou El-Bizri
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Decks in this class (25)
Ion channels structure and function
What are ion channels 1,
Electrochemical gradient definiti...,
What are the 3 key components of ...
12
cards
Ion channels pharmacology
What are the domains of an ion ch...,
Historical examples of ion channe...,
Subunit selectivity and influence...
10
cards
Patch clamp electrophysiology and single channel recording
Electrophysiology definition and ...,
Resistors and capacitors and thei...,
Current and voltage clamp 3
8
cards
Modelling ion channels
Describe what kinetic models aim ...,
Describe the flaws with the simpl...,
Describe the del castillo katz mo...
6
cards
intro to kinase drug discovery
What are kinases and their major ...,
Describe basic rtk signaling usin...,
Describe the mapk pathway activat...
9
cards
how kinases work
Describe the general protein kins...,
Describe how the catalytic domain...,
Describe catalytic domain activat...
4
cards
modes of small molecule kinase inhibitor action
What are type 1 kinase inhibitors 1,
What are type 2 kinase inhibitors 2,
What are type 3 4 kinase inhibito...
8
cards
irreversible inhibitors and mechanism of resistance
List the mechanisms of kinase inh...,
How can mechanisms of kinase inhi...,
How does inhibitor potency differ...
8
cards
modelling ion channels -H
Different types of ion channel mo...,
Del castillo katz model overview 2,
Limitations of the castillo katz ...
5
cards
Introduction to kinase drug discovery -H
What is a kinase what are their t...,
Rtk activation and downstream sig...,
Jak signalling cascade mechanisms...
7
cards
How kinases work -H
What are the conserved and non co...,
Kinases overall structure lobes a...,
Kinase architecture and skeletal ...
4
cards
modes of small molecule inhibitors actions -H
Type i kinase inhibitors overview...,
Type ii kinase inhibitors bcr and...,
Type iii kinase inhibitors mechan...
5
cards
Irreversible inhibitors and mechanisms of resistance -H
Physical mechanisms of resistance...,
Mechanisms of resistance in signa...,
Examples and mechanisms of mutati...
9
cards
Intro to RTK's
Common domains in all rtks 1,
Factor in dimerisation of insulin...,
Egfr dimerisation 3
11
cards
EGFR
Different egfr isoforms and their...,
Egf ligands and their signalling ...,
Hb egf mechanisms and signalling 3
9
cards
VEGFR
Vegf roles and ligand isoforms 1,
Vegf a structure and alternative ...,
What regulates the alternative sp...
11
cards
Intro to GPCRs
Different examples of gpcr stimuli 1,
General structure of gpcrs 2,
Classes of gpcrs and structural c...
9
cards
GPCRs 2
Describe the simple linear two st...,
Describe the ternary complex model 2,
Historic and modern way of detect...
6
cards
GPCRs efficacy
What is a receptor reserve and ho...,
What is signal amplification 2,
What factors does potency and ema...
6
cards
GPCRs biased agonism
What is biased agonism 1,
Example of at1 biased agonism and...,
Example and outcome of at1r biase...
8
cards
GPCRs drug binding kinetics
What is a closed vs an open system 1,
Law of mass action what is kon an...,
Method of experimentally measurin...
14
cards
GPCRs allostery
Orthosteric and allosteric bindin...,
Parameters defining allosteric ki...,
Assay for allosteric modulator bi...
8
cards
Intro to structural biology - GPCRs
What type of structures are there...,
Protein folding and its regulation 2,
Proteolysis of adhesion gpcrs 3
9
cards
GPCRs structural biology 2
Timeline of drug discovery 1,
B ar overview and drug discovery 2,
How machine learning is developed 3
6
cards
Physiological insights of GPCRs
Factors to consider when identify...,
Approaches to understanding gpcr ...,
Dreadds overview and uses 3
7
cards
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Molecular pharmacology and advanced quantitative pharmacology
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