PATH30001

Toxic injury: Alcohol-induced disease To use alcohol as an example of: variations involved in the outcome of chemically induced cellular injury - acute and chronic inflammation does the molecule interact directly with cellular components? do metabolic products of the molecule interact with cellular components? If so - how and with what outcome? How is the molecule or its product/s distributed throughout the body? What are the cellular and molecular effects?

- that the properties of the host and the infectious agent determine the pathogenic consequences of infection - properties of H. pylori that contribute to disease - properties of the host that determine the outcome of H. pylori infection - pathogenesis of disease caused by infection of the gastrointestinal tract - treatment versus cure of disease

To understand the relationship between the host defences (respiratory tract), infecting organisms (bacteria, viruses, fungi), and chemicals or trauma in lung injury. The general mechanisms causing acute and chronic inflammation and changes is cells and tissues due to the host response. 1. lung defences and loss of defences 2. pneumonia syndromes 3. inflammatory responses 4. acute inflammation in the lung - bacterial pneumonia - ALI - ARDS 5. chronic inflammation features

- understand the purpose of the acute inflammatory response - know the key cellular-molecular interactions occurring during the different phases of acute inflammation - understand which key mediators and which pathways induce the acute inflammatory process

- to gain an understanding of the process of healing at the cellular and molecular level - to understand the interrelationships of each stage of the healing process - to be able to apply this knowledge to gain insight into the pathology of chronic disease and tissue repair

diseases of white blood cells and lymph nodes - to be able to give examples of major diseases covered in the lecture involving WBCs and lymph nodes - to gain an understanding of the signs, molecular basis and treatments of major diseases involving white blood cells and lymph nodes

Immune System-induced diseases 1 Overview of the immune system - innate and adaptive immunity - cells and molecules involved When the immune system fails - primary immunodeficiency (PID) - e.g. CVID, SAD

- immunological tolerance -- central tolerance -- peripheral tolerance - when tolerance fails -- autoimmune diseases -- allergy

arthritis: a chronic disease of the joints 1. pathology and pathophysiology of - arthritis - osteoarthritis 2. structure and function of - cartilage - type II collagen - aggrecan 3. research in action - mechanism of cartilage destruction in OA

Coeliac Disease - gluten-sensitive enteropathy

Ulcerative colitis and crohn's disease

Reactions to Injury of the Liver - 1

liver disease 2

Pathology of Renal Injury 1 - normal structure and (very basic) function - general comments about renal disease -- who gets it? is it common? -- how is it diagnosed? what does it lead to? - the common and important causes of renal injury – acute and chronic

pathology in renal injury 2 - that 'chronic' generally means irreversible as well (but current research on the potential reversibility of fibrosis is challenging some of that) - the common causes of chronic renal failure in Australia today (and tomorrow) and their major pathological features - that CRF presents clinically when damage is extensive

Asthma to understand: - the aetiology and pathology of asthma - where asthma fits in to COPD to consider: - some of the questions relating to the aetiology of asthma 1. normal airway structure 2. asthma - definition and types 3. asthma - pathogenesis: - atopic asthma - attempts to explain: data --> hypotheses - other types of asthma 4. Asthma: morphology 5. what you should know

Fibrosing Diseases of the lung - what is the significance of fibrosis in lung disease? - what is IPF? - how is it diagnosed? - what are some of the explanations for aetiology and pathogenesis? - what are the main cellular players? - how can we do research on this disease? - how could it be treated or cured?

Food Allergy Future therapies