Flashcards in 10. ANS Deck (14)
What enzyme found at the NMJ breaks down acetylcholine?
What is tolterodine an example of?
Antagonist of mAChR to treat overactive bladder
What are pyridostigmine and donepezil an example of?
Pyridostigmine treats myasthenia gravis
Donepezil treats Alzheimer's disease
What side effects can a non selective muscarinic agonist lead to?
Decreased heart rate and cardiac output
Increased bronchoconstriction, GI peristalsis, sweating, salivation
What can muscarinic agonists be used to treat?
Allow bladder emptying
What can muscarinic antagonists treat?
What is the process by which noradrenaline is formed?
How is NA action terminated?
Uptake 1 - terminated via a Na+ dependant high affinity transporter
Uptake 2 - lower affinity non neuronal mechanism
How is NA metabolised?
How does amphetamine affect NA release?
Taken up into vesicles leading to NA being displaced leading to it leaking into the synaptic cleft
Amytriptyline is an uptake 1 inhibitor, what can this lead to?
Massive sympathetic side effects
Name 2 beta 2 adrenoreceptor agonists
What can alpha 1 antagonists treat?