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Flashcards in 10. ANS Deck (14)
1

What enzyme found at the NMJ breaks down acetylcholine?

Acetylcholinesterase

2

What is tolterodine an example of?

Antagonist of mAChR to treat overactive bladder

3

What are pyridostigmine and donepezil an example of?

Acetylcholinesterase inhibitors
Pyridostigmine treats myasthenia gravis
Donepezil treats Alzheimer's disease

4

What side effects can a non selective muscarinic agonist lead to?

Decreased heart rate and cardiac output
Increased bronchoconstriction, GI peristalsis, sweating, salivation

5

What can muscarinic agonists be used to treat?

Glaucoma
Allow bladder emptying

6

What can muscarinic antagonists treat?

Asthma
COPD
Overactive bladder

7

What is the process by which noradrenaline is formed?

Tyrosine
DOPA
Dopamine
Noradrenaline

8

How is NA action terminated?

Uptake 1 - terminated via a Na+ dependant high affinity transporter

Uptake 2 - lower affinity non neuronal mechanism

9

How is NA metabolised?

Monoamine oxidase
Catechol-O-methyl transferase

10

How does amphetamine affect NA release?

Taken up into vesicles leading to NA being displaced leading to it leaking into the synaptic cleft

11

Amytriptyline is an uptake 1 inhibitor, what can this lead to?

Massive sympathetic side effects

12

Name 2 beta 2 adrenoreceptor agonists

Salbutamol
Salmeterol

13

What can alpha 1 antagonists treat?

Hypertension

14

What enzyme allows the synthesis of acetyl choline from Acetyl CoA and choline?

Choline acetyl transferase