2013

Question 1

List 4 societies that families can turn to for PID support

Answer 1

1. Immunodeficiency Canada
2. Canadian immunodeficiencies patient organization
3. immune deficiency foundation
4. national organization for rare disorders (NORD)
5. Jeffrey model foundation

Question 2

Patient cant afford medications what options do you have?

Answer 2

1. Offer samples
2. Try an alternative that is covered
3. Refer to social work for stipends
4. apply for compassionate coverage

Question 3

what are the mechanisms of vaccines reactions

Answer 3

1. IgE mediated - very rare
2. delayed hypersensitivity
3. mild local reactions

Question 4

explain the concept of clonal diversity

Answer 4

B cells create progeny cells generated by mitosis which are considered clone, some of those will have divergence which is consider clonal expansion

Question 5

what happens to a naive T cell after activation?

Answer 5

• naive T cell are programmed in the thymus for a particular antigen
• once released they circulate until they find this surface antigen via APCs
• T cells become activated once they bind to their APC which the correct MHC molecule
• the MHC-antigen complex activates the TCR and enables T cell to secrete cytokines

Question 6

what receptor binds CD28?

Answer 6

CD80 and CD81

Question 7

what is the immune barrier hypothesis of chronic rhinosinusitis?

Answer 7

1. defects in mechanical and innate immune protective barrier
2. leads to passage of antigens across nasal epithelium leads to chronic inflammatory infiltrate
3. defect comes from genetic, epigenetic and environmental influences

Question 8

what concentrations do you use for SPTs and ID testing?

Answer 8

SPT - 100 mcg/ml

ID - 1 mcg/ml

Question 9

what is skeeter syndrome?

Answer 9

large local reaction to mosquito bites

can occurs hours after bit occurs

Question 10

how many kids outgrow peanut allergy?

Answer 10

20% outgrow peanut
10% for TN
50% for soy at age 7

Question 11

allergens in occupational asthma for the following

1. Baker
2. jeweller
3. painter
4. hair dresser
5. auto shop
6. healthcare worker

Answer 11

1. flour
2. nickel
3. isocyanates
4. PPD and CPBD, dyes and bleaches
5. isocyanates
6. latex

Question 12

CR of legume and peanut

Answer 12

3-5%

Question 13

CR of cows and goat milk

Answer 13

high! 80%

Question 14

labs to order in Heiner syndrome

Answer 14

IgG milk

CBC for anemia and eosinophilia