Drugs

Question 1

CYP3A

Answer 1

Substrates: Cyclosporine mechanism: genetically less important than other drug metabolism genes b/c activity continuous and unimodal

Question 2

Ketoconazole, grapefruit juice inhibit….

Answer 2

CYP3A

Question 3

Rifampin induces…

Answer 3

CYP3A

Question 4

CYP2D6

Answer 4

Substrates: Tricyclic antidepressants and codeine (activates codeine->morphine)

Question 5

Quinidine, Fluoxetine, Paroxetine inhibit…

Answer 5

CYP2D6

Question 6

CYP2C9

Answer 6

Substrates: Warfarin

Question 7

20% of caucasians need lower dose of ….. because they are poor metabolizers

Answer 7

Warfarin

Question 8

NAT

Answer 8

Modifies risk of cancers though differences in acetylation of carcinogens, Important in Phase II pathway

Question 9

Isoniazid for TB mechanism

Answer 9

Acts on NAT

Question 10

TMPT

Answer 10

5% of kids with ALL (leukemia) poor metabolizers (absent activity)–> will KILL child (immunosuppression) if don’t test for it (functional assay)

Question 11

6-mercaptopurine, 6-thioguanine

Answer 11

Acts on TMPT

Question 12

G6PD

Answer 12

X-linked enzyme -Deficient individuals susceptible to hemolytic anemia after sulfa or dapsone drug exposures

Question 13

Sulfonamide antibiotics, dapsone are substrates for…

Answer 13

G6PD

Question 14

VKORC1

Answer 14

VKORC1 reduces vitamin K so that vitamin K can be recycled and used to make more coagulation factors

Question 15

Warfarin acts on…

Answer 15

VKORC1