final lecture 2

Question 1

____ are leading causes of death in SLE pts

Answer 1

complications of therapies & infection

Question 2

goals of SLE therapy

Answer 2

ensure long-term survival
induction & maintenance of remission
improve QOL
minimize complications associated w/ treatments

Question 3

non-drug SLE therapy

Answer 3

rest & exercise, avoid stress, smoking cessation, limit sun exposure, counseling & support services

Question 4

when to use NSAIDs for SLE

Answer 4

fever, arthritis, skin rash, erositis (manage inflammation & pain)

Question 5

decrease in renal function may be a side effect of

Answer 5

NSAIDs, rather than lupus nephritis

Question 6

use ____ in all SLE pts

Answer 6

antimalarials

Question 7

hydroxychloroquine dose

Answer 7

200-400mg/day

Question 8

chloroquine dose

Answer 8

250-500mg/day

Question 9

key monitoring for antimalarials

Answer 9

eye exams

Question 10

onset of antimalarials

Answer 10

prolonged- may need steroid bridge therapy

Question 11

when to use corticosteroids

Answer 11

more serious clinical manifestations, SLE symptoms unresponsive to other meds

Question 12

steroid dose

Answer 12

mild: 10-20mg/day
severe: 1-2mg/kg/day

Question 13

steroid pulse dosing

Answer 13

IV bolus 500-1000mg X3-6 days methylprednisolone followed by 1-1.5mg/kg/day prednisone

Question 14

role of steroids in life-threatening disease

Answer 14

severe active nephritis, CNS invlvement, hemolytic disease

Question 15

pulse dose steroids may be

Answer 15

quicker response & decreased side effects compared to long-term

Question 16

prophylaxis needed w/ corticosteroid use

Answer 16

osteoporosis

Question 17

when to use immunosuppresive agents

Answer 17

in combo w/ steroids for lupus nephritis

Question 18

cyclophophamide is useful for

Answer 18

induction of remission

Question 19

azathioprine is useful for

Answer 19

mainenance of remission

Question 20

biologic agents used in SLE

Answer 20

belimumab & rituximb

Question 21

when to use biologics

Answer 21

in combo w/ other agents to induce remission for refractory lupus

Question 22

____ should not be placed on belimumab

Answer 22

african americans

Question 23

meds that can cause SLE

Answer 23

procainamide & hydralazine

Question 24

SLE chacteristics

Answer 24

15-45yo, females >males, common malar rash, psych symptoms

Question 25

drug-induced lupus

Answer 25

usually older age, no gender predominance , malar rash rare, musculoskeletal mst common