Drugs Test 1

Question 1

Zidovudine

Answer 1

aka AZT.

Class: nucleoside reverse transcriptase inhibitor)

MOA: Thymidine analog that blocks RT at active site.

Question 2

Efavirenz

Answer 2

Class: Non-nucleoside RT inhibitor (NNRTI).

MOA: Binds RT far from active site

Question 3

Raltegrovir

Answer 3

Class: Entry inhibitor

MOA: inhibits catalytic activity of HIV integrase

Question 4

Ritonavir

Answer 4

Class: Protease inhibitor

MOA: Inhibits protease that is needed for proper protein synthesis.

Question 5

Maroviroc

Answer 5

Class: entry inhibitor

MOA: Chemokine receptor 5 antagonist which prevents entrance of HIV.

Question 6

Foscarnet

Answer 6

Antiviral

MOA: structural mimic of the anion pyrophosphate that selectivelys inhibits the pyrophosphate binding site on viral DNA pol. at concentrations that don’t affect human DNA pol.

Question 7

Cidofir

Answer 7

Inhibitor of viral DNA pol that has much higher affinity for viral DNA pol.

Question 8

Ganciclovir/Acyclovir

Answer 8

Nucleotide analog that is phosphorylated by viral kinases and highly preferred by viral DNA pol. Terminates viral DNA replication.

Acyclovir - Thymidine Analog - Alpha Herpes Viruses
Ganciclovir - Guanosine Analog - Beta and Gamma Herpes viruses