EBV Follow-Up--Skildum

Question 1

EBV uses this receptor for entering B-cells

Answer 1

C3d receptor/CD21 (B-cell latent infection)

Question 2

Which portion of EBV binds the C3d receptor/CD21?

Answer 2

GP 350/220 (B-cell latent infection)

Question 3

What is the primary gene responsible for unimpaired proliferation of B-cells in EBV infections?

Answer 3

LMP1

Question 4

LMP1 is what?

Answer 4

constitutively active CD40 on B-cells

–> NF-kB activation

Question 5

LMP2 is what?

Answer 5

constitutively active B-cell receptor

–> MAPK pathway, proliferation and cell survival

Question 6

How does EBNA3C act on B-cells?

Answer 6

activate cyclin D1

binds nuclear antigen 3C

Question 7

What is the classic triad of infectious mononucleosis?

Answer 7

pharyngitis, lymphadenopathy, fever

Question 8

What does the monospot test screen for?

Answer 8

heterophile antibodies made by polyclonal expansion of B-cells

Question 9

What atypical lymphocyte is seen in EBV infectious mono?

Answer 9

Downey cells

Question 10

Retinoblastoma is:
tumor suppressor gene or
oncogene

Answer 10

tumor suppressor gene

Question 11

Cyclin D1 is:
tumor suppressor gene or
oncogene

Answer 11

proto-oncogene

Question 12

What is fulminant infectious mono?

Answer 12

X-linked lymphoproliferative disease

Question 13

Pathology of X-linked lymphoproliferative disease

Answer 13

SAP mutation, does not turn off SLAM and leads to unchecked lymphocyte proliferation

Question 14

What is the average survival of X-linked lymphoproliferative disease?

Answer 14

1-2 mo.