Anti-inflammatory drugs

Question 1

First generation H1 antagonist

sedative effects (crosses BBB-not p-GP substrate)

Answer 1

diphenhydramine

Question 2

First gen H1 antagonist

less sedative effect–suitable for daytime use

Answer 2

chlorpheniramine

Question 3

Second gen H1 antagonists (2)

available OTC

Answer 3

Cetirizine (Zyrtec)

Loratidine (Claritin)

Question 4

Second gen H1 antagonist

Rx

Answer 4

Fexofenadine

Question 5

5-lipoxygenase inhibitor

prevent synthesis of LTB4 and peptidoleukotrienes (LTC4, D4, E4)

Answer 5

zileuton

Question 6

LTC4 receptor and Cys LTR1 inhibitor

P450 metabolism –> drug interaction risk

Answer 6

Zafirlukast

Question 7

LTC4 receptor and Cys LTR1 inhibitor

once daily admin, no food restrictions

Answer 7

Montelukast

Question 8

Irreversibly inhibits COX1

Answer 8

acetylsalicylate

Question 9

Inhibits COX 1 and 2

shorter acting

fewer side GI side effects

OTC

Answer 9

ibuprofen

Question 10

inhibits COX 1 and 2

longer acting

OTC

Answer 10

Naproxen

Question 11

COX 1 and 2 inhibitor

primarily for analgesia

IV admin?

Answer 11

ketorolac

Question 12

Strongest COX 1 and 2 inhibitor

severe GI side effects

Answer 12

indomethacin

Question 13

COX 1 and 2 inhibitor

once daily admin

severe dose related GI bleeding

Answer 13

Piroxicam

Question 14

What is Sulindac?

Answer 14

another prescription NSAID

Question 15

Selective COX 2 inhibitor

Answer 15

celecoxib

Question 16

Weak COX inhibitor

minimal anti-inflammatory effects

toxic with EtOH

Answer 16

acetaminophen