Hyperlipidemia Flashcards
US adults with total cholesterol over 200
100mil
percent children under 15 and pts 21-39 with fatty streaks
50, 85
vulnerable plaque
large lipid core, thin fibrous cap, macrophages interacting with thrombus
stable plaque
reduced lipid core, thick fibrous cap, increased smooth muscle
screening frequency ACA/AHA v USPSTF
ACA: 4-6yrs, USPSTF: 5yrs (lipids and ASCVD risk)
reducing sat. fat to 5-6% of diet can lower LDL by
11-13mg/dL, 11%
pts w/clinical ASCVD
high intensity statin (40 atorva)
pts w/LDL>190
high intensity statin (40 atorva) grade B
pts age 40-75 w/DM and LDL 70-189
get 10y ASCVD risk! moderate if under 7.5, high if over
moderate dose statin
atorva 10, simva 20-40, prava 40, lova 40
pts w/o CVD or DM, LDL 70-189 and CVD over 7.5
mod to high dose statin
prevalence of myopathy in statins
1-20% (lower w/CoQ10?)
prevalence of rhabdo in statins
under .06%
prevalence of liver fox
under 1.5 in 5 year use
ALT cutoff for statins
increase over 3x normal