Disease antibody associations Flashcards

1
Q

Polymyositis/scleroderma overlap

A

PM/SCL antibody

5-10%

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2
Q

Necrotising myopathy

A
Anti SRP (signal recognition protein)
Confers poor prognosis
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3
Q

Dermatomyositis

A

Anti Mi-2

Anti Jo-1

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4
Q

Ask for myositis associated antibodies and get…

A

Anti Jo-1 (most common- 20% of PM/DM)
Anti-Mi-2
Anti-SRP
PM/SCL

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5
Q

What are the sensitivity and specificity of the american college of rheumatology criteria in diagnosing RA in early disease?

A

Sens 40-60%

spec 80-90%

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