Therapeutic Antibodies for Cancer Part 1 Flashcards
Define Tumor Targeting Antibodies
Monoclonal antibody designed to target oncoproteins expressed by tumor cells and to cause an immune response that destroys cancer cells
Define Immunomodulatory Antibody:
Monoclonal antibodies specifically interacts with immuno-regulatory molecules, which elicits or restores an existing anti-cancer immune response.
Define Adoptive T cell Transfer:
A treatment using host T cells to boost the natural ability of immune activity to fight cancer.
Define Immunostimulatory Cytokines:
Multiple functional proteins that play important roles in body’s immune responses and have the immune-regulatory activity to control cancer cell growth. The two main types of cytokines used to treat cancer are interferon-α/β and interleukin-2.
Define Cancer-Therapeutic Vaccines:
Antigen-presenting cells (APC) to stimulate immune response against cancer.
Define Innate Immunity Agonists:
Bacillus Calmette-Guérin (BCG): An innate immunity-stimulus
Define Monoclonal Antibodies (mAbs):
Produced from a single B lymphocytes, either from mouse, human or other species.
Define Murine mAbs
Derived entirely from mouse, usually mouse hybridoma cells by the fusion of mouse myeloma cells with spleen B-cells.
Define Chimeric mAbs:
Variable regions derived from a murine source and the constant regions derived from a human source.
Define Humanized mAbs:
Antigen-binding sequences (CDRs) derived from a mouse and all others from a human source. (less mouse, more human)
Define Human mAbs:
Derived entirely from a human source
Define Naked Therapeutic Antibody
Simple antibody
Define Conjugated Therapeutic Antibody
Antibody carrying chemotherapy or isotopes (ADC or AIC)
Define Immuno-Regulatory Therapeutic Antibody
Remove the inhibitory signals and restore T cell response
Define Bispecific Antibody
One side interacts with T cell immune response and the other carries chemotherapy or isotopes
