Antiretroviral Agents Med Chem Flashcards
Which of these medications inhibits Viral attachment and entry into the host cell? (select all)
A. Enfuviritide
B. Efavirenz
C. Saquinavir
D. Zidovudine
E. Raltegravir
F. Maraviroc
A. Efuvirtide
B. Maraviroc
These medications do not follow any particular similar naming sequence so they stand out in this class of medications. The others do follow similar patterns in their naming sequences that you will see shortly.
Which of these medications are NRTIs (nucleoside/nucleotide reverse transcriptase inhibitors)? Select All
A. Zidovudine
B. Efavirenz
C. Raltegravir
D. Stavudine
E. Emtricitabine
F. Saquinavir
A. Zidovudine
B. Stavudine
C. Emtricitabine
NRTIs= dine/bine
EXCEPTION: Abacavir and Tenofovir do not end in dine or bine but they are NRTIs
Which of these medications are NNRTIs (Non-nucleoside Reverse Transcriptase Inhibitor)? Select All
A. Raltegravir
B. Efavirenz
C. Nevirapine
D. Zidovudine
E. Etravirine
B. Efavirenz
C. Nevirapine
E. Etravirine
Non-nucloside Reverse Transcriptase Inhibitors (NNRTI) have “vir” in their name as do other anti-virals BUT NNRTIs have “vir” at the middle of their names, NOT at the end of their names.
EXCEPTION: Maraviroc has VIR in the middle of its name but is NOT an NNRTI.
Which of these medications is an Integrase inhibitor?
A. Zidovudine
B. Abacavir
C. Efavirenz
D. Saquinavir
E. Raltegravir
E. Raltegravir
Raltegravir has “tegra” in its name and resembles the word Integrase.
Which of these medications inhibits Viral Maturation (Protease inhibitors)? Select All
A. Saquinavir
B. Zidovudine
C. Tenofovir
D. Ritonavir
E. Maraviroc
F. Amprenavir
A. Saquinavir
D. Ritonavir
F. Amprenavir
Protease inhibitors=“navir”
Just make sure you look out for that extra N so you don’t confuse it with other vir medications.
Which of these viral enzymes can undergo mutation in order to increase resistance to the Antretroviral Agents?
A. Integrase
B. Protease
C. Transcriptase
D. All of the above
D
These are all drug targets so the virus can mutate them in order to increase resistance to these medications.
What are the target host cells for HIV?
A. Macrophages
B. CD4 T-lymphocytes (T-Cells)
C. Blood cells
D. Dendritic cells
B
Macrophages were the host cells of M.Tuberculosis Not viruses.
