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Microbiology > Antiviral Drugs > Flashcards

Antiviral Drugs Flashcards

1
Q

Inhibitors of early events (5)

A

Amatadine, Rimantadine
Enfuvirtide
Maraviroc
Palivizumab

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3
Q

Afftected virus - amantadine

A

Influenza A

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4
Q

Prevents Uncoating (2)

A

Amantadine & Rimantadine

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5
Q

Side effects - amantadine

A

CNS alterations; dizziness, ataxia, insomnia

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6
Q

Alternate drug - amantadine

A

Rimantadine

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7
Q

Affected virus - Enfurvirtide

A

HIV virus

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8
Q

Mechanism - amantadine

A

Blocks ion channel of M2 matrix proteins; prevents uncoating; no transcription

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9
Q

Affected virus - Maraviroc

A

HIV virus

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10
Q

Mechanism - Enfurvirtide

A

Binds gp41; fusion inhibitor

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11
Q

Affected virus - Palivizumab

A

Respiratory syncytial virus

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12
Q

Mechanism - Palivizumab

A

Monoclonal antibody; binds to fusion protein of virus

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13
Q

Uses - Palivizumab

A

Prevents bronchiolitis & pneumonia in premature and immunocompromised patients

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14
Q

Inhibitors of Herpes virus - nucleoside inhibitors (6)

A 
Acyclovir - famciclovir, valacyclovir & penciclovir
Ganciclovir - valganciclovir
Cidofovir
Vidarabine
Idoxuridine
Trifluoridine
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15
Q

Inhibitors of Herpes virus - non-nucleoside inhibitors (1)

A

Foscarnet

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16
Q

Mechanism - Acyclovir

A

Guanosine analog
Monophosphorylated by HSV/VZV encoded THYMIDINE KINASE
Triphosphate formed by Cellular kinases
Inhibits viral DNA polymerase by chain termination

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17
Q

Clinical use - Acyclovir

A

HSV 1&2 and VZV; no CMV
No affect on latent forms

Hsv —> genital lesions & encephalitis

18
Q

Side effects - Acyclovir

A

CNS toxicity & renal toxicity (obstructive crystalline nephropathy & acute renal failure)

19
Q

Valacyclovir & famciclovir

A

Valacyclovir - herpes genitalis & zoster

Famciclovir - herpes zoster

20
Q

Mechanism- Maraviroc

A

Binds CCR-5; fusion inhibitor; prevents interaction of gp120 with CCR-5; docking inhibitor

Microbiology (46 decks)

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