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ESA 2 - Infection > Epstein Barr Virus > Flashcards

Epstein Barr Virus Flashcards

1
Q

what type of virus is EBV

A

group 1 (dsDNA)

herpes family

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2
Q

how is EBV transmitted

A

infected saliva

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3
Q

what type of infection (acute/chronic/latent) does EBV cause

A

latent

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4
Q

which cells does EBV infect

A
  1. initially replicates in oropharyngeal epithelium

2. progeny viruses infect B cells (via C3bR) - latency and B cell immortalisation

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5
Q

what is the main disease caused by EBV

A

infectious mononucleosis (glandular fever)

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6
Q

what are the symptoms of IM

A

classical clinical triad:

  1. fever
  2. pharyngitis
  3. lymphadenopathy (cervical lymph node enlargement)

can also present with splenomegaly, headache and malaise

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7
Q

which malignancies can arise from EBV infection

A
  1. Burkitt’s lymphoma

2. Nasopharyngeal carcinoma

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8
Q

what is the most common cause of viral gastroenteritis

A

norovirus

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9
Q

what type of virus is norovirus

A

group IV (ssRNA)

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10
Q

what type of infection (acute/chronic/latent) does norovirus cause

A

acute

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11
Q

how is norovirus transmitted

A
  1. faecal-oral route
  2. person-to-person

is v. contagious

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12
Q

in which cell type does norovirus replicate

A

small intestine cells

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13
Q

describe the management of norovirus gastroenteritis

A

supportive: fluids, antiemetics, antidiarrhoeals

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14
Q

what type of virus is adenovirus

A

dsDNA

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15
Q

describe the structure of adenovirus

A
  • non-enveloped

- unique fibre associated with each penton base of capsid

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16
Q

how is adenovirus transmitted

A

inhalation of airbornevirus - highly contagious

17
Q

in which cell type does adenovirus replicate and how does it enter these cells

A
  • replicates in epithelial cells, e.g. resp. tract, eye, intestine and urinary tract
  • fibre protein binds to cell R (CD46)… penton base protein interacts with integrin… endocytosis via clathrin-coated pits
18
Q

what diseases can adenovirus cause

A
  1. respiratory infections, e.g. viral pneumonia, acute resp. disease, acute febrile pharyngitis
  2. GI infections - infantile gastroenteritis
  3. occular infections
  4. urinary tract infections
19
Q

how is norovirus diagnosed

A

ELISA of stool specimens

20
Q

which antiviral can be used to treat herpes simplex and varicella zoster

A

acyclovir

21
Q

what is the MOA of acyclovir

A

inhibits viral DNA polymerase

22
Q

which antiviral can be used to treat influenza A and B

A

oseltamivir (Tamiflu)

23
Q

what is the MOA of oseltamivir

A

inhibits viral neuraminidase

ESA 2 - Infection (25 decks)

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