415 Exam 3 Drugs Flashcards

1
Q

What are the initial ISTI therapies for HIV

A

Dolutegravir/Emtricitabine/Tenofovir DF or alafenamide

Elvitegravir/cobicistat/Emtricitabine/Tenofovir DF or alafenamide

Raltegravir/Emtricitabine/Tenofovir DF or alafenamide

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2
Q

What are the initial PI therapies for HIV

A

Darunavir/Ritonavir/Emtricitabine/Tenofovir DF or alafenamide

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3
Q

Preventative therapy for heterosexual transmission of HIV-1

A

1% Tenofovir gel

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4
Q

Preventative therapy for MSM transmission of HIV-1

A

Truvada QD

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5
Q

DOC for pneumocystic jiroveci pneumonia (PJP)

A

Trimethoprim sulfamethoxazole (Bactrim) 15-20 mg/kg/d divided in 3-4 doses for 21 days

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6
Q

DOC for toxoplasmic encephalitis

A

Pyrimethamine 50-100mg QD + sulfadiazine 1-2g QID for 6-12 weeks

Clindamycin 2.4g QD + pyrimethamine 50mg QD

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7
Q

DOC for prophylaxis of MAC

A

Clarithromycin 500mg BID or Azithromycin 1200mg QW

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8
Q

DOC for MAC

A

Clarithromycin 500mg BID + Ethambutol 15mg/kg QD

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9
Q

DOC candidiasis

A

Fluconazole 100-200mg QD

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10
Q

DOC for cryptococcosis prophylaxis

A

Fluconazole 100-200mg QD for life

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11
Q

DOC for cryptococcosis

A

Amphotericin B 0.5-1 mg/kg + Flucytosine 100 mg/kg/d divided into QID

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12
Q

DOC histoplasmosis prophylaxis

A

Itraconazole 200mg BID

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13
Q

DOC for CMV

A

Ganicyclovir 5-6 mg/kg 5-6 days/week or 1000mg TID

Foscarnet 90-120 mg/kg QD

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14
Q

DOC herpes simplex virus

A

Acyclovir 200mg TID or 400mg BID

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15
Q

DOC for hepatitis B

A

Tenofovir + Emtricitabine

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16
Q

DOC children with acute otitis media

A

Amoxicillin 90 mg/kg/d divided into BID or TID for 10 days (Max 3000mg/d)

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17
Q

DOC acute pharyngitis

A

Penicillin vk (Veetids, PenVeeK)
Children: 250mg BID-TID for 10 days
Adults: 250mg TID-QID or 500mg BID for 10 days

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18
Q

DOC acute sinusitis

A

Amoxicillin Clavulanate (Augmentin) for 10 days

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19
Q

DOC for epiglottitis

A

Ceftriaxone (Rocefin) 80-100 mg/kg q12h or Cefotaxime (Claforan) 150-225 mg/kg q6h
PLUS
Vancomycin or Nafcillin for 10 days

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20
Q

DOC outpatient CAP

A

Azithromycin (Zithromax) 500mg QD for 7-10 days

Doxycycline (Vibramycin) 100mg BID 10-14 days

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21
Q

DOC outpatient CAP w/ CHF or COPD

A

Beta lactam + macrolide

Cefpodoxime 400mg BID 
Cefurozime axetil 500mg BID 
Augmentin 1g q8h 
Plus 
Azithromycin or Doxycycline
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22
Q

DOC inpatient non-severe pneumonia

A

Azithromycin (Zithromax) 500mg IV QD + beta lactam (ampicillin/sulbactam, Ceftriaxone, cefotazime)

Doxycycline (Vibramycin) 100mg IV BID + beat lactam
(ampicillin/sulbactam, Ceftriaxone, ceftazidime)

Levofloxacin (Levaquin)

23
Q

DOC inpatient severe pneumonia w/o risk factors for pseudomonas

A

Cefotaxime or Ceftriaxone PLUS Azithromycin or Fluoroquinolone

24
Q

DOC for HAP or VAP

A
Cefepime 2g q8h 
Imipenem 500-1000mg q6h 
Meropenem 1g q8h 
Zosyn 4.5g q8h 
PLUS
Levofloxacin 750mg q24h 
Aminoglycoside 
PLUS 
Vancomycin if MRSA suspected 
For 7-14 days (21 days if pseudomonas)
25
Q

DOC outpatient bacterial infection infants-pre-school

A

Amoxicillin

26
Q

DOC inpatient bacterial infections infants-pre-school

A

Ceftriaxone or Cefotaxime

27
Q

DOC outpatient bacterial infection school age children

A

Macrolide

28
Q

DOC inpatient bacterial infection school age children

A

Beta lactam + macrolide

29
Q

DOC for S. pneumonia (MIC <2)

A

Ampicillin

30
Q

DOC S. pneumoniae (MIC >2)

A

Ceftriaxone

31
Q

DOC for MSSA

A

Cefazolin

32
Q

DOC for MRSA

A

Vancomycin

33
Q

DOC for Group A Strep

A

Penicillin G

34
Q

DOC for H. influenzae

A

Ampicillin or Ceftriaxone

35
Q

DOC for Mycoplasma pneumoniae

A

Azithromycin

36
Q

DOC for Chlamydia trachomatis

A

Azithromycin

37
Q

DOC for complicated acute bronchitis

A

Macrolide
Doxycycline
Amoxicillin Clavulanate
2nd/3rd CPN

38
Q

RSV prophylaxis therapy

A

Palivizumab (Synagis) 15 mg/kg IM monthly Nov-April

39
Q

DOC for E. coli HAI

A

Ceftriaxone
Zosyn or Unasyn
Ampicillin +/- aminoglycoside

40
Q

DOC for ESBL HAI

A
Ertapenem
Meropemem (anti-pseudomonas)
41
Q

DOC for Non-MRSA S. aureus HAI

A

Oxacillin
Nafcillin
Cephazolin

42
Q

DOC for MRSA S. aureus HAI

A

Vancomycin

Linezolid

43
Q

DOC for Enterococci HAI

A

Ampicillin + Gentamicin
Vancomycin + Gentamicin
Linezolid

44
Q

DOC pseudomonas UTI HAI

A

Fluoroquinolone

Aminoglycoside

45
Q

DOC for pseudomonas non-UTI HAI

A

Zosyn + Aminoglycoside

Ceftazidime or Cefepime + Aminoglycoside

46
Q

DOC for Non-MRSE Staph epidermidis HAI

A

Penicillin G

47
Q

DOC for MRSE Staph epidermidis

A

Vancomycin

Linezolid

48
Q

DOC surgical prophylaxis

A

Adults: Cefazolin 2g (3g > 120kg)
Children: Cefazolin 30mg/kg

49
Q

DOC GI tract surgical prophylaxis

A

Cefoxitin 2g

50
Q

DOC latent TB

A

Isoniazid 300mg QD for 9 months

51
Q

DOC for prevention of peripheral neuropathy with Isoniazid

A

Pyridoxine (vit B6) 25-50mg daily

52
Q

DOC for active TB (initial phase)

A

Isoniazid + Rifampin + Ethambutol + Pyrazinamide

Daily or 5 days a week for 2 months

53
Q

DOC for active TB (continuation phase)

A

Isoniazid + Rifampin

Daily or 5 days a week for 6 months