Breast ca Flashcards
1
Q
WLE + radiotx
A
Equivalent to mastectomy
2
Q
Chemotherapy for breast ca
A
Anthracyclines /taxanes
3
Q
Gonadotoxic
A
Cylophosphamide
4
Q
Beware interaction between tamoxifen and CYP2D6
A
SSRI, SNRI
5
Q
Traztuzumab is always given with chemotherapy
A
Idiosyncratic cardiotoxicity, but mostly reversible
No CNS penetration –> cerebral mets often sanctuary site
6
Q
trastuzumab/emtansine
A
Antibody drug conjugate for targeted delivery to cell
Thrombocytopenia MAIN side effect
7
Q
+ve axillary LN is the worst prognostic factor
A
followed by triple negative
8
Q
BRCA are TSG (DNA repair gene)
A
AD with variable penetrance
Prostate and pancreatic cancer also have association
