A/49

Question 1

Type of heredity of FamHC?

Answer 1

autosomal dominant

Question 2

Frequency of familial hypercholesterolemia?

Answer 2

1 / 500

Question 3

Difference between homozygotes and heterozygotes in familial hypercholesterolemia?

Answer 3

• heterozygotes : 2-3 increase of cholesterol level

- homozygotes : up to 5x increase & younger

Question 4

Clinical presentations of familial hypercholesterolemia? (2)

Answer 4

• skin and tendon sheath xanthomas

- premature AS

Question 5

Drugs used to treat familial hypercholesterolemia?

Answer 5

Statins

Question 6

Pathogenesis of FamHC?

Answer 6

• Impaired transport of LDL : high plasma levels

- Impaired IDL