Acute Leukemia

Question 1

Acute Lymphoblastic Leukemia (ALL)

Answer 1

Newborn - 14 years old

TdT(+)

Question 2

B-ALL

Answer 2

t(12;21): good prognosis

CD10, CD19, CD20

Commonly metastasize to testicles and CNS

Question 3

T-ALL

Answer 3

CD10(-), CD2-8(+)

Can present as thymic mass

Tend to metastasize to skin

Question 4

Acute Myeloblastic Leukemia (AML)

Answer 4

MPO(+)

APL, AMoL (Acute Monocytic Leukemia), Acute Megakaryoblastic Leukemia

Question 5

Acute Promyelocytic Leukemia (APL)

Answer 5

DIC, Auer rods, t(15,17)

RAR is disrupted –> high doses of ATRA (all-trans retinoic acid) may induce remission –> differentiation into neutrophils –> apoptosis

Question 6

Acute Megakaryoblastic Leukemia

Answer 6

Increased incidence in Down Syndrome (<3 yrs)