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Flashcards in Adaptive Immunology Deck (32):
1

IgM

-Produced first
-sign of acute infection
-activate classical complement
-primary BCR

2

IgD

-BCR
-secreted in upper respiratory mucosa

3

IgG

-most abundant
-opsonization
-ADCC
-cross placenta
-activates classical complement
-4 subtypes

4

IgA

-mucosal immunity
-mono or dimeric
-2 subtypes
-mother's milk

5

IgE

-allergy
-helminth defense

6

Th1 cells secrete

IFN-gamma

7

Th2 cells secrete

IL-4, IL-5, IL-13

8

Th17 cells secrete

IL-17 and IL-22

9

Th1 general function

Macrophage-mediated killing of intracellular pathogens

10

Th2 general function

Antibody-mediated immunity to extracellular parasites, asthma/allergy

11

Th17 general function

Immune response to extracellular fungi/bacteria; autoimmunity

12

Antigen processing of MHCII is of...

Extracellular microbes/antigen

13

Antigen processing of MHCI is of...

Intracellular microbe

14

MHCII

1.) phagolysosome digestion
2.) ER, alpha and beta chains associate with Ii
3.) Exocytosis
4.) MHCII-Ii to lysosome>>digested>>CLIP>>HLA-DM>>high affinity foreign peptide
5.) Loaded MHCII to surface>>recognized by naive CD4

15

MHCI

1.) intracellular microbes produce protein in cytosol of cell
2.) ubiquitin>>proteasome>>peptide
3.) to ER via TAP
4.) MHCI with TAP via tapasin
5.) peptide cleaved by ERAP then bound to MHCI
6.) MHCI dissociates and exits via exocytosis to surface>>recognized by CD8

16

MHCI genes

HLA-A
HLA-B
HLA-C

17

MHCII genes

HLA-DP - alpha and beta
HLA-DQ - one of two alphas and beta
HLA-DR - alpha, beta 1 and 0 or 1 of (3,4,5)

18

Lymphoid tissue homing receptors

CCR7 on cells
CCL19/21 ligands in lymph

19

DCs receptors

ICAM-1, B7, cytokines for T cell proliferation (IL-2)

20

Multipotent progenitor cells receptors to home to thymus

CCR9/CCL25

21

pro-T cell marker

CD2+

22

Bone marrow stromal cells secrete...

SCF, Kit, IL-7

23

surrogate light chain proteins

VpreB, lambda-5

24

B cells home to primary follicle using chemokines...

CXCL13, CXCR5

25

Costimulatory molecules for T-cell activation

CD28:B7

26

APC secretes these cytokines for Th1 differentiation

IFN-gamma, IL-12

27

APCs secrete this cytokine for Th2 differentation

IL-4

28

APCs secrete these cytokines for Th17 differentiation

IL-1, IL-6, TGF-beta

29

IL-17 induces tissue cells to secrete...

TNF, IL-1, IL-6

30

Stem cell marker

CD34

31

B cell markers

CD10, CD19

32

T cell markers

CD2, CD3, CD4, CD8