What drugs increase DA in the nucleus accumbens?
Nicotine, alcohol, opiates, cocaine
Some factors that increase propensity towards addiction
Drug’s effects on D2 receptors
They decrease them (tolerance). When you’re clean for 4 mo, start to come back…don’t revert to normal right away
D2 effects on drugs
People with high D2 levels had an unpleasant response to stimulants. Low had a pleasant response
What parts of the brain were activated with cocaine craving?
Anterior cingulate and the amygdala