list the antiarrhythmics that risk torsades
All class Ia (quinidine, disopyramide, procainamide) and sotalol, dofetilide, ibutilide, and amiodorone
what drugs can’t be given in combo with aniarrhythmics that risk TDP?
- amitriptyline (tricyclic)
- erythromycin and clarithromycin (macrolide)
- levofloxacin and gatifloxacin (fluoroquinolones)
- chlorpromazine and thioridazine (antipsychotics)
what is the restricted access class III antiarrhythmic
dofetilide
what disease states are included in Atherosclerotic CV Disease
coronary heart disease
stroke
peripheral arterial disease
what is included in clinical ASCVD
acute coronary syndromes MI hx angina stroke TIA
what anticoagulants should be used for pre-cardioversion anticoagulation
- warfarin
lmwh (full dose)
dabigatran
list high intensity statin options
atorvastatin 40-80 mg
rosuvastatin 20-40 mg
a patient on amiodarone, amlodipine or ranolazine should not receive more than how much simvastatin
20 mg daily
a patient on verapamil or diltiazem should not exceed how much simvastatin daily
10 mg daily
what are the determinants of oxygen demand often targeted by drug tx for chd?
- heart rate
- contractility
- systolic wall tension
what are the determinants of wall tension
- systolic or intraventricular pressure (afterload)
- ventricular size and shape (preload)
- ventricular wall thickness
what determins oxygen supply
- coronary blood flow
- oxygen content of arterial blood
- amount of oxygen extracted by myocardium
what is the goal hemoglobin A1C
less than 7
what ca blockers increase o2 supply to
diltiazem
verapamil
amlodipine
what are the thienopyridines
- clopidogrel
- prasugrel
- ticlopidine
what is the moa of thienopyridines
inhibit adp-induced platelet aggregation by blocking adp from recepotr
list the glycoprotein inhibitors
what is there moa
abciximab
eptifibatide
tirofiban
inhibit final step in platelet aggregation
