Antidepressants

Question 1

What is key with antidepressants?

Answer 1

safety safety safety

bc of increased risk of suicide within the first week of taking it

Question 2

What are the different SSRIs

Answer 2

1. Citalopram
2. Escitalopram
3. Fluoxetine
4. Paroxetine
5. Sertraline

Question 3

What are SSRIs useful in tx for?

Answer 3

1. Depression w anxiety
2. Panic disorder
3. PTSD
4. OCD
5. bulimia

Question 4

Side effects of SSRIs

Answer 4

1. Sleep disturbance
2. Sexual dysfunction
3. Reduced appetite
4. Rash/SJS
5. Tension headaches
6. Hyponatremia

Question 5

How long does it take SSRIs to take full effect?

Answer 5

2-3 weeks for full effect

Question 6

Symptoms of serotonin syndrome

SHIVERS

Answer 6

Shivering
Hyperreflexia
Increased temp
VS instability
Encephalopathy
Restlessness
Sweating

Question 7

Do SSRIs increase bleeding tendencies?

Answer 7

YES

Question 8

What are the different SNRIs?

Answer 8

1. Venlafaxine
2. Desvenlafaxine
3. Duloxetine
4. Levomilnacipran

Question 9

Do SSRIs and SNRIs have the same symptoms?

Answer 9

yes

Question 10

What are SNRIs useful in tx for?

Answer 10

1. MDD
2. anxiety disorder

Question 11

What are the adverse effects of SNRIs?

Answer 11

Serotonin syndrome
Hyponatremia

Question 12

What is trazodone used for?

Answer 12

mainly used for sleep but its an antidepressant

Question 13

What should be known about trazodone?

Answer 13

1. extremely sedating
2. CAN be given in adjunct with SSRIs

Question 14

What is an adverse effect of Trazodone?

Answer 14

Priapism

aka painful erect penisssss

Question 15

What are the different TCAs?

Answer 15

1. Amitriptyline
2. Doxepin
3. Imipramine
4. Nortriptyline

Question 16

What stimulating effects do TCAs target?

Answer 16

Target fatigue and lethargy

Question 17

What sedating effects do TCAs target?

Answer 17

target agitation or restlessness

Question 18

What are the anticholinergic side effects of TCAs?

Answer 18

1. Dry Mouth
2. Blurred vision
3. Tachycardia
4. Constipation
5. Urinary retention
6. Esophageal reflux
7. Photophobia
8. Sexual dysfunction

Question 19

What two anticholinergic effects of TCAs are considered a medical emergency?

Answer 19

constipation and urinary retention

Question 20

How long odes it take for TCAs to reach full effect?

Answer 20

4-8 weeks

Question 21

What are the adverse effects of TCAs?

Answer 21

1. orthostatic hypotension
2. Dysrythmias
3. MI
4. Heart block

Question 22

Which medication class is very cardio toxic?

Answer 22

TCAs

Question 23

What are the contraindications of TCAs?

Answer 23

1. Recent MI
2. Narrow angle glaucoma
3. Benign prostatic
4. Hypertrophy
5. seizures
6. preggo

Question 24

What are the different MAOIs?

Answer 24

1. Phenelzine
2. Tranylcypromine
3. Isocarboxazid
4. Selegiline

Question 25

What can MAOIs cause?

Answer 25

HTN crisis

Question 26

What are the symptoms of a HTN crisis?

Answer 26

1. Severe HA or blurry vision 2. chest pian 3. tachycardia 4. SOB 5. Diaphoresis 6. Anxiety 7. Mental status change 8. confusion N/V

Question 27

If switching from SSRI to MAOI how long is the wash out period?

Answer 27

5 week cleanse

Question 28

if switching from MAOI to SSRI how long is the cleanse?

Answer 28

14 days

Question 29

What foods do you avoid when taking MAOIs?

Answer 29

tyramine foods need to be avoided **Will cause HTN if eaten**

Question 30

What are the contraindications of MAOIs?

Answer 30

1. CVD 2. HTN 3. CHF 4. liver disease 5. recurrent ot severe HA 6. Recent surgery

Question 31

Which antidepressant is mainly used for smoking cessation and prevention of seasonal depression?

Answer 31

Buproprion

Question 32

What are the adverse effects of bupropion?

Answer 32

1. Appetite suppression 2. seizures

Question 33

What medication targets suicide ideation?

Answer 33

Ketamine

Question 34

How can Ketamine be administered?

Answer 34

IV and nasal

Question 35

What are the side effects of ketamine?

Answer 35

increased BP, HR Disassociation

Question 36

alternative treatments for depression

Answer 36

light therapy st johns wort