Biochem - Metabolism (Part 1) Flashcards Preview

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Flashcards in Biochem - Metabolism (Part 1) Deck (200)
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1

Fatty acid oxidation occurs in the _____ (mitochondria/cytoplasm), whereas fatty acid synthesis occurs in the _____ (mitochondria/cytoplasm).

Mitochondria; cytoplasm

2

Glycolysis occurs in the _____ (mitochondria/cytoplasm), whereas the Krebs cycle occurs in the _____ (mitochondria/cytoplasm).

Cytoplasm; mitochondria

3

Where in the cell are the enzymes of the hexose monophosphate shunt located?

In the cytoplasm

4

Where in the cell does acetyl coenzyme A production occur?

In the mitochondria

5

Protein synthesis occurs on the _____ (rough/smooth) endoplasmic reticulum, whereas steroid synthesis occurs on the _____ (rough/smooth) endoplasmic reticulum.

Rough; smooth

6

Name the three pathways that occur in both the cytoplasm and the mitochondria.

Heme synthesis, the Urea cycle, and Gluconeogenesis; remember the mnemonic: HUGs take two

7

Name four pathways that occur exclusively in the mitochondria.

Fatty acid oxidation, acetyl-CoA production, Krebs cycle, and oxidative phosphorylation

8

Describe the function of a kinase.

An enzyme that utilizes adenosine triphosphate to add high-energy phosphate group onto substrate

9

Describe the function of a phosphorylase.

An enzyme that adds inorganic phosphate onto substrate without utilizing adenosine triphosphate

10

Describe the function of a phosphatase.

An enzyme that removes phosphate group from substrate

11

Describe the function of a dehydrogenase.

An enzyme that oxidizes substrate

12

Describe the function of a carboxylase.

An enzyme that adds one carbon with biotin as a cofactor

13

What is the rate-determining enzyme of de novo pyrimidine synthesis?

Carbamoyl phosphate synthetase II

14

Carbamoyl phosphate synthetase II is the rate-limiting enzyme of which metabolic process?

De novo pyrimidine synthesis

15

What is the rate-determining enzyme of de novo purine synthesis?

Glutamine-phosphoribosyl pyrophosphate amidotransferase

16

Glutamine-phosphoribosyl pyrophosphate amidotransferase is the rate-limiting enzyme of which metabolic process?

De novo purine synthesis

17

What is the rate-determining enzyme of glycolysis?

Phosphofructokinase-1

18

Phosphofructokinase-1 is the rate-limiting enzyme of which metabolic process?

Glycolysis

19

What is the rate-determining enzyme of gluconeogenesis?

Fructose-1,6- bisphosphatase

20

Fructose-1,6- bisphosphatase is the rate-limiting enzyme of which metabolic process?

Gluconeogenesis

21

What is the rate-determining enzyme of the tricarboxylic acid cycle?

Isocitrate dehydrogenase

22

Isocitrate dehydrogenase is the rate-limiting enzyme of which metabolic process?

The tricarboxylic acid cycle

23

What is the rate-determining enzyme of glycogen synthesis?

Glycogen synthase

24

Glycogen synthase is the rate-limiting enzyme of which metabolic process?

Glycogen synthesis

25

What is the rate-determining enzyme of glycogenolysis?

Glycogen phosphorylase

26

Glycogen phosphorylase is the rate-limiting enzyme of which metabolic process?

Glycogenolysis

27

What is the rate-determining enzyme of the hexose monophosphate shunt?

Glucose-6-phosphate dehydrogenase

28

Glucose-6-phosphate dehydrogenase is the rate-limiting enzyme of which metabolic process?

The hexose monophosphate shunt

29

What is the rate-determining enzyme of fatty acid synthesis?

Acetyl-CoA carboxylase

30

Acetyl-CoA carboxylase is the rate-limiting enzyme of which metabolic process?

Fatty acid synthesis