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Flashcards in Bugs and MOR Deck (38)
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1

MSSA

-NSBLs

2

MRSA

-NSBLs
-modified PBPs
*only requires single point mutation and high mutation rate to FQs

3

MSSE

-90% make NSBLs
-empirically assume it's MRSE

4

MRSE

-NSBLs
-modified PBPs

5

PSSP

-don't make beta-lactamases

6

PRSP

-don't make beta-lactamases
-modified PBPs
functionally resistant
*very slow mutation rate to develop FQ resistance…not a lot of gyrase resistance. Main target is PAR for FQ…main resistance is efflux pumps!

7

Any other streptococci

-no beta-lactamases
-strep. viridans most resistant of these

8

Enterococcus faecalis

-no beta-lactamases
-modified PBPs
-VRE=modified PTG to become vancomycin resistant

9

Enterococcus faecium

-no beta-lactamases
-modified PBPs
-VRE=modified PTG to become vancomycin resistant

10

Listeria monoctyogenes

-no beta-lactamases
-modified PBPs
-PBPs are similar to enterococci but their ribosome is more similarto traditional G+ bugs (so macrolides work)

11

Corynebacterium

-modified PBPs (similar to enterococci)

12

Bacillus

-no beta-lactamases

13

Acinetobacter

-modified PBPs
-modified pores
-70-90% make BSBL
-some can make carbapenamases
only requires single point mutation and high mutation rate to FQs

14

Moraxella catarrhalis

-"simple G-"
-20-50% make BSBL (up to 75%)

15

Neisseria gonorrhea

-20-50% make BSBL
-some have modified PBP-->if it does, NO penicillin will work

16

Neisseria meningitidis

-"simple G-"
-no beta-lactamases
-some have modified PBPs (PRNM)
-vaccine available!

17

Haemophilus influenza

-"simple G-"
-20-50% make BSBL
-vaccine available!
*many strains (<50% but still significant) have become resistant to marcolides via mef genes

18

Pasturella/Eikenella

-"simple G-"
-no beta-lactamases

19

Escherichia coli

-20-50% make BSBL
-possible to make IRBSBL which chops up ALL penicillins
-20% make ESBL (more likely to see in hospital infections)
*requires multiple mutations and relatively slow rate of mutation for FQ resistance

20

Salmonella

-20% make BSBLs

21

Shigella

-20% make BSBLs

22

Proteus mirabilis

-least likely to make beta-lactamases
--if it does make one, it's BSBL

23

Proteus vulgaris

-most make BSBL
-modified PBPs

24

Klebsiella

-70-90% make BSBL
-20% make ESBL
-some make carbapenamases

25

Citrobacter (Morganella, Providencia)

-70-90% make BSBL
-20% make AmpC but this gene is usually repressed

26

Enterobacter

-70-90% make BSBL
-20% make AmpC but gene usually repressed
-some make carbapenamases

27

Serratia

-70-90% make BSBL
-20% make AmpC but gene usually repressed
-some make carbapenamases

28

Pseudomonas aeruginosa

-restrictive outer membrane
-70-90% make BSBLs
-20% make AmpC
-some make carbapenamases
-unique PBPs
some resistance by modified porins to Aztreonam
*only requires single point mutation and high mutation rate to FQs…get end treatment resistance!!

29

Stenotrophomonas maltophilia

-make carbapenamases

30

Burkholderia cepacia

-multiple MOR