Flashcards in Bugs and MOR Deck (38)
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1
MSSA
-NSBLs
2
MRSA
-NSBLs
-modified PBPs
*only requires single point mutation and high mutation rate to FQs
3
MSSE
-90% make NSBLs
-empirically assume it's MRSE
4
MRSE
-NSBLs
-modified PBPs
5
PSSP
-don't make beta-lactamases
6
PRSP
-don't make beta-lactamases
-modified PBPs
functionally resistant
*very slow mutation rate to develop FQ resistance…not a lot of gyrase resistance. Main target is PAR for FQ…main resistance is efflux pumps!
7
Any other streptococci
-no beta-lactamases
-strep. viridans most resistant of these
8
Enterococcus faecalis
-no beta-lactamases
-modified PBPs
-VRE=modified PTG to become vancomycin resistant
9
Enterococcus faecium
-no beta-lactamases
-modified PBPs
-VRE=modified PTG to become vancomycin resistant
10
Listeria monoctyogenes
-no beta-lactamases
-modified PBPs
-PBPs are similar to enterococci but their ribosome is more similarto traditional G+ bugs (so macrolides work)
11
Corynebacterium
-modified PBPs (similar to enterococci)
12
Bacillus
-no beta-lactamases
13
Acinetobacter
-modified PBPs
-modified pores
-70-90% make BSBL
-some can make carbapenamases
only requires single point mutation and high mutation rate to FQs
14
Moraxella catarrhalis
-"simple G-"
-20-50% make BSBL (up to 75%)
15
Neisseria gonorrhea
-20-50% make BSBL
-some have modified PBP-->if it does, NO penicillin will work
16
Neisseria meningitidis
-"simple G-"
-no beta-lactamases
-some have modified PBPs (PRNM)
-vaccine available!
17
Haemophilus influenza
-"simple G-"
-20-50% make BSBL
-vaccine available!
*many strains (<50% but still significant) have become resistant to marcolides via mef genes
18
Pasturella/Eikenella
-"simple G-"
-no beta-lactamases
19
Escherichia coli
-20-50% make BSBL
-possible to make IRBSBL which chops up ALL penicillins
-20% make ESBL (more likely to see in hospital infections)
*requires multiple mutations and relatively slow rate of mutation for FQ resistance
20
Salmonella
-20% make BSBLs
21
Shigella
-20% make BSBLs
22
Proteus mirabilis
-least likely to make beta-lactamases
--if it does make one, it's BSBL
23
Proteus vulgaris
-most make BSBL
-modified PBPs
24
Klebsiella
-70-90% make BSBL
-20% make ESBL
-some make carbapenamases
25
Citrobacter (Morganella, Providencia)
-70-90% make BSBL
-20% make AmpC but this gene is usually repressed
26
Enterobacter
-70-90% make BSBL
-20% make AmpC but gene usually repressed
-some make carbapenamases
27
Serratia
-70-90% make BSBL
-20% make AmpC but gene usually repressed
-some make carbapenamases
28
Pseudomonas aeruginosa
-restrictive outer membrane
-70-90% make BSBLs
-20% make AmpC
-some make carbapenamases
-unique PBPs
some resistance by modified porins to Aztreonam
*only requires single point mutation and high mutation rate to FQs…get end treatment resistance!!
29
Stenotrophomonas maltophilia
-make carbapenamases
30
