C1

Question 1

antiseptics

Answer 1

Ethanol+isopropanol: Denature proteins( The second is more effective but also more dangerous)

Povidone iodine is Halogen: on skin

H2O2: Mouth wash, wounds

Chlorhexidone: Hospital scrub rutine. Ototoxicity!!

Octenidin: against gram + and gram - (antiseptic prior to medical procedures)

Invert soaps = synthetic detergent

Question 2

Disinfection vs Sterilization

Answer 2

Disinfection; reduce amount of potential pathogenes
Sterilization: Removal. complete elimination

Disinfectant is on non living surface
Antidecptic on living surface

Question 3

considerations in Antimicrobial therapy

Answer 3

1. spectrum of action
2. site of infection (incl. degree of tissue penetration
3. pharmacodynamic, pharmacokinetics
4. dosage
5. adverse effects
6. presence of renal/hepatic failure
7. drug interactions
8. cost

Question 4

types of antimicrobial therapy

Answer 4

1. empiric treatment : based on clinical presentation
2. definitive therapy: based on microbio results/ sensitivity test
3. prophylactic therapy ( immunocomprimised, asplenic)