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Flashcards in Cancer Chemotherapy General. Deck (20):
1

Regarding the different modalities of cacner treatment, when is surgery considered as an option? (select all)

A. When cancer has become hematologic 

B. When tumor is solid

C. When tumor is localized

D. When cancer is not localized

B. When tumor is solid

C. When tumor is localized

2

Regarding the different modalities of cancer treatment, when is Radiation considered as an option? (select all)

A. Tumor is solid

B. Cancer has spread amongst the majority of the body

C. Tumor is localized

D. Surgery alone could cause more harm than good

E. Tumor is not localized 

A. Tumor is solid

C. Tumor is localized

D. Surgery alone could cause more harm than good

3

Regarding the different modalities of cancer treatment, when is Systemic Treatment considered? (Select All)

A. Tumor is localized

B. Tumor is solid

C. Cancer is not localized

D. Cancer is spread to multiple organs

C. Cancer is not localized

D. Cancer is spread to multiple organs

4

Which of the following is an approach to Systemic Therapy in the treatment of cancer? (Select all)

A. Chemotherapy

B. Targeted therapy

C. Biologic Response Modifier

D. Focal surgery

E. Endocrine therapy

A. Chemotherapy

B. Targeted therapy

C. Biologic Response Modifier

E. Endocrine therapy

5

What is Adjuvant Therapy?

A. When chemotherapy is used as pretreatment then radiation is used to remove the remaining cancer cells

B. When radiation is used as pretreatment then chemotherapy is used to remove the remaining cancer cells

C. Chemotherapy is given ahead of surgery or radiation and used to stop tumor growth

D. None of the above

B. When radiation is used as pretreatment then chemotherapy is used to remove the remaining cancer cells

6

What is neo-adjuvant therapy?

A. Chemotherapy is given ahead of surgery or radiation and used to stop tumor growth

B. Radiation or surgury is done first then chemotherapy to remove remaining cancer cells

C. Chemotherapy is started during the process of radiation and surgery and discontinued immediatly after the surgery or radiation treatment is complete

D. None of the above

A. Chemotherapy is given ahead of surgery or radiation and used to stop tumor growth

7

T/F 

Antineoplastic agents exhibit great selectivity towards cancer cells rather than human cells

False

8

Why do chemotherapeutic agents lack selectivity in their action? (select all)

A. Cancer cells originate from our own cells

B. Similar morphological and biochemical properties between cancer cells and our own cells. 

C. Morphological and biochemical differences between our cells and normal cells are very different

D. Both the cancer cells and our own cells spend the majority of their time in the G0 phase

E. Lack of distinctive characteristics between our cells and cancer cells.

A. Cancer cells originate from our own cells

B. Similar morphological and biochemical properties between cancer cells and our own cells. 

E. Lack of distinctive characteristics between our cells and cancer cells.

9

What feature of the cell cycle accounts for some selective toxicity for antineoplastic agents? (Select all)

A. Drugs that target the G1 phase will not affect our human cells

B. Our normal human cells spend most of their time in G0 phase (resting phase)

C. Cancer cells spend most of their time in the G0 phase (resting phase)

D. Chemotherapeutic medications have a more pronounced effect on cells (cancer or human) when they are in any phase of the cell cycle and are not in the Gphase. 

E. Cancer cells do not enter the G0 phase and are actively replicating

B. Our normal human cells spend most of their time in G0 phase (resting phase)

D. Chemotherapeutic medications have a more pronounced effect on cells (cancer or human) when they are in any phase of the cell cycle and are not in the G0 phase. 

E. Cancer cells do not enter the G0 phase and are actively replicating

10

What is the cell-kill hypothesis?

A. Relates to the magnitued of normal cells killed by chemotherapy with each round of anticancer drugs

B. Relates to the magnitude of tumor and cancer cells killed by chemotherapy with each round of anticancer drugs

C. Relates to the magnitude of tumor and cancer cells that have regenerated despite chemotherapy and anticancer drug adnimistration

D. None of the above

B. Relates to the magnitude of tumor and cancer cells killed by chemotherapy with each round of anticancer drugs

11

Why are several rounds of chemotherapy given with rest periods? (Select All)

A. Several rounds of chemotherapy are needed because remaining cancer cells can still replicate

B. Several rounds are given because decreasing as many human cells as possible will decrease the chances of the cancer spreading to other healthier cells.

C. The rest period is given to allow normal cells to regenerate from the chemotherapy

D. The rest period is given to allow adequate time for cancer cells to enter the Gphase and remain dormant. 

A. Several rounds of chemotherapy are needed because remaining cancer cells can still replicate

C. The rest period is given to allow normal cells to regenerate from the chemotherapy

12

Why are chemotherapy drugs given in combination? (Select All)

A.  Multiple drugs cover many mechanisms of action and act at different areas of the cell cycle or indipendent of cell cycle.

B. Decreases the likelihood of therapy failure

C. Allows for multiple mechanisms of resistance to develop

D. Allows for the selection of multiple medications in order to treat the condition and manage the drug selection based on side effect profile

A.  Multiple drugs cover many mechanisms of action and act at different areas of the cell cycle or indipendent of cell cycle.

B. Decreases the likelihood of therapy failure

D. Allows for the selection of multiple medications in order to treat the condition and manage the drug selection based on side effect profile

13

Antimetabolites will specifically target the __ phase of the cell cycle.

A. G1

B. S

C. G2

D. M

B. S-Phase

14

Epipodophyllotoxins specifically target ___.

A. Topoisomerase I

B. Topoisomerase II

C. NA/K/ATPase pumps

D. Cancer cell mitochondria

B. Topoisomerase II

15

Camptothecins will target the __ phase of the cell cycle.

A. G1 phase

B. S phase

C. G2 phase

D. M phase

B. S phase

16

Taxanes will target the ___ phase of the cell cycle.

A. G1 phase

B. S phase

C. G2 phase

D. M phase

D. M phase

17

Vinca Alkaloids will target the ___ phase of the cell cycle

A. G1 phase

B. S phase

C. G2 phase

D. M phase

D. M phase

18

Which of the follwing is an Acute toxicity with chemotherapy drugs? (Select all)

A. Alopecia

B. Anemia

C. Nausea/Vomiting

D. Skin necrosis

A. Alopecia

B. Anemia

C. Nausea/Vomiting

 

The reason for this is because chemo agents decrease fast-cell proliferation. Hair, bone marrow (blood cells) and GI cells are ALL fast-cells when it comes to proliferation

19

Which of the following are delayed toxicities of chemotherapy agents? (select all)

A. Cardiotoxicity

B. Kidney disorders

C. Hair loss

D. Anemia

A. Cardiotoxicity

B. Kidney disorders

 

These occur due to free radical formation and cause damage over time. Hence why you see these effects anywhere from weeks to years after treatment. 

20

T/F

Acute toxicities are generally irreversible while delayed toxicities are generally reversible

False