Cell membrane structure
Phospholipid bilayer
Also known as fluid mosaic structure
Function of cell membrane
Structural integratiy/support
Transport of material in & out of the cell
Components of cell membrane
1)Phospholipid
2)Membrane Lipid
3)Cholesterol
4)Glycocalyx (Glycolipid & Glycoprotein)
Components of phospholipid
1)A glycerol molecule
2)2 fatty acid chain
3)Phosphate head
Phospholipid is _______.Why?
Amphipathic
Hydrophilic due to phosphate head
Hydrophobic due to fatty acid tail
Phospholipid forms as _______ in cell.
lipid bilayer (hydrophobic inside & phodrophilic outside)
Two phospholipids layers have different composition.True or False?
True
bcus of the attachment of head gp(choline,spingosine) at the phosphate.
Types of membrane protein
1)Integral protein
2)Periphral protein
Integral protein
Transmembrane proteins that entirely or partially penerate the lipid bilayer
Peripheral protein
Loosely attached to the membrane surface (inner or outer side)
Glycocalyx are
Oligosacchride chain is attached to
Membrane protein-glycoprotein
Membrane lipid-glycolipid
Function of membrane protein
1)Cell junction
2)Recognation (glycoprotein)
3)Channel & carrier protein
4)Receptor
5)Enzymes
6)Attachment to outside or inside of the cell
Is cholesterol amphipathic?
Slightly amphipathic bcus of the -OH gp
Function of glycoprotein & glycolipid
Cell to cell recognition
eg.blood type
To be able to function properly,cell membrane can’t be
too fluid or too rigid
Fluditiy of cell membrane is controlled by
1)Phospholipid
2)Cholesterol
3)Temperature
What will happen when membrane phospholipid contain many unsaturated fatty acid tail?
Prevent tightly packing of phospholipid>increase membrane fluidity
What will happen when membrane phospholipid contain many saturated fatty acid tail?
Tightly packing of phospholipid>decrease fluidity
Temperature & memebrane fluidity
Increase temp>increase fluidity
Decrease temp>decrease fluidity
What control the membrane fluidity according to temperature ?
Cholesterol
How cholesterol control membrane control membrane fludity at high temeprature?
High temperature>increase fluidity
*Cholesterol reduces the membrane fluidity
How cholesterol control membrane control membrane fludity at low temperature?
Low temperature>decrease fluidity>rigid
*Cholesterol increases the membrane fluidity
Cell membrane is______.
Semipermeable(selectively permeable) bcus of the amphipathic character
______ can pass through the cell membrane by DIFFUSION.
Small nonpolar molecules(hydrocarbon,steroid hormones & O2,CO2)
Ions(small) & water molcules can diffuse but slow