CMV2

Question 1

What are uses for Letermovir

Answer 1

prophylaxis of CMV reactivation

in HSCT recipients who are CMV+, receiving a transplant from any donor

If HSCT recipient CMV-, they will instead receive valganciclovir

Question 2

What is dose of letermovir

What is duration of letermovir

Answer 2

480mg OD

100 days

Costs £3000

Question 3

What is mechanism of action of letermovir

Answer 3

Letermovir is a cytomegalovirus DNA terminase complex inhibitor that interferes with cytomegalovirus genome formation and virion maturation